Isolation, structural analyses and biological activity assays against chronic lymphocytic leukemia of two novel cytochalasins - sclerotionigrin A and B

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spe...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2014-07, Vol.19 (7), p.9786-9797
Main Authors: Petersen, Lene M, Bladt, Tanja T, Dürr, Claudia, Seiffert, Martina, Frisvad, Jens C, Gotfredsen, Charlotte H, Larsen, Thomas O
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
apergilli
Apoptosis - drug effects
Apsergillus sclerotioniger
Aspergillus
Biological activity
Cancer
Cell Line, Tumor
Cell Survival - drug effects
chronic lymphocytic leukemia
cytochalasins
Cytochalasins - chemistry
Cytochalasins - isolation & purification
Cytochalasins - pharmacology
Electronic mail systems
Humans
Leukemia
Leukemia, Lymphocytic, Chronic, B-Cell
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
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Summary:Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules19079786