Comparative Study on the Efficacy of Lignocaine Nebulisation Vs Topical Lignocaine Spray in Attenuation of Haemodynamic Surge in Patients Undergoing Surgery Under General Anaesthesia - A Single Blinded Randomized Controlled Study

• Published in: Journal of medical sciences and health (Online) 2024-04, Vol.10 (1), p.52-58
• Main Authors: Roy, Amrita, Sofiullah, Md, Bandyopadhyay, Debasis, Manuar, Md Babrak, Ray, Utpal Kumar, Hajra, Bimal Kumar
• Format: Article
• Language: English
• ISSN: 2394-9481; 2394-949X
• DOI: 10.46347/jmsh.v10.i1.23.473

Introduction: Laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated. The present study is to compare the efficacy of lignocaine nebulisation vs topical lignocaine spray in attenuation of haemodynamic surge in patients undergoing surgery under general anaesthesia. Methodology: After ethical committee clearance, a single blind randomized control study was done on sixty patients of either sex aged between 18-55 years of ASA status I undergoing elective surgery under general anaesthesia with endotracheal intubation. Patients were randomly allocated into 2 groups: GROUP A:received nebulised Lignocaine Hydrochloride 4% at 2 mg/kg. GROUP B: received Topical Lignocaine spray 10% at 2mg/kg. Heart rate, Systolic, diastolic and mean blood pressure was documented before administering premedication (T0), at the time of intubation (TI) and at 1min (T-1), 2min (T-2) & 5min (T-5) after intubation. Attenuation in HR, SBP, DBP and MBP were found statistically significant (p