Trends in the prevalence, prenatal diagnosis, and outcomes of births with chromosomal abnormalities: a hospital-based study in Zhejiang Province, China during 2014-2020

To investigate the prevalence and prenatal diagnosis rate of chromosomal abnormalities (CA) in Zhejiang Province, China. We estimated the annual changes in the detected prevalence of CA and prenatal diagnosis rate among 681,590 births in Zhejiang Province, China, between 2014 and 2020. Data were der...

Full description

Saved in:
Bibliographic Details
Published in:Orphanet journal of rare diseases 2022-12, Vol.17 (1), p.446-446, Article 446
Main Authors: Chen, Xinning, Lin, Dan, Ye, Yinghui, Zhang, Xiaohui, Chen, Danqing
Format: Article
Language:English
Subjects:
Adult
Birth defects
China - epidemiology
Chromosome Aberrations
Down Syndrome
Female
Genetic aspects
Health aspects
Hospitals
Humans
Pregnancy
Pregnant women
Prenatal Diagnosis
Prevalence
Prevention
Risk factors
Sex Chromosome Aberrations
Technology application
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the prevalence and prenatal diagnosis rate of chromosomal abnormalities (CA) in Zhejiang Province, China. We estimated the annual changes in the detected prevalence of CA and prenatal diagnosis rate among 681,590 births in Zhejiang Province, China, between 2014 and 2020. Data were derived from the provincial birth defects surveillance system, which represents 30% of annual births in Zhejiang Province. The effect of maternal age was also evaluated. The detected prevalence of sex chromosomal abnormalities (1.70-7.30 per 10,000 births, P  
ISSN:1750-1172
1750-1172
DOI:10.1186/s13023-022-02594-1