Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex

Unsatisfactory efficacies of currently recommended anti- complex (MABC) treatment regimens have led to development of novel drugs to combat MABC infections. In this study, we evaluated in vitro antimicrobial activities of bedaquiline (BDQ) and four oxazolidinones against MABC isolates. The resazurin...

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Published in:Infection and drug resistance 2023-01, Vol.16, p.279-287
Main Authors: Gao, Tianhui, Yao, Cong, Shang, Yuanyuan, Su, Renchun, Zhang, Xuxia, Ren, Weicong, Li, Shanshan, Shu, Wei, Pang, Yu, Li, Qi
Format: Article
Language:English
Subjects:
Antimicrobial activity
Antimicrobial agents
bedaquiline
Drug development
Drug therapy, Combination
Health aspects
Infection
Laboratories
Linezolid
Medical research
Medicine, Experimental
Mycobacterium abscessus
mycobacterium abscessus complex
Nosocomial infections
Original Research
Oxazolidinones
Statistical analysis
susceptibility testing
tedizolid
Tuberculosis
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Summary:Unsatisfactory efficacies of currently recommended anti- complex (MABC) treatment regimens have led to development of novel drugs to combat MABC infections. In this study, we evaluated in vitro antimicrobial activities of bedaquiline (BDQ) and four oxazolidinones against MABC isolates. The resazurin microplate assay was performed to determine minimum inhibitory concentrations (MICs) of BDQ and four oxazolidinones, including tedizolid (TZD), sutezolid (SZD), delpazolid (DZD), and linezolid (LZD), against 65 MABC isolates. A checkerboard method was used to investigate efficacies of various antimicrobial drug combinations. BDQ MICs for MABC isolates ranged from
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S395750