Community-based diabetes prevention randomized controlled trial in refugees with depression: effects on metabolic outcomes and depression

Depression and antidepressant medications increase risk for type 2 diabetes. Cambodian-Americans have exceedingly high rates of both depression and diabetes. This paper reports outcomes of a diabetes prevention trial for Cambodian-Americans with depression. Primary outcomes were HbA1c, insulin resis...

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Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.8718-8718
Main Authors: Wagner, Julie A., Bermúdez-Millán, Angela, Buckley, Thomas E., Buxton, Orfeu M., Feinn, Richard S., Kong, Sengly, Kuoch, Theanvy, Scully, Mary F.
Format: Article
Language:English
Subjects:
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Antidepressants
Antidepressive Agents - therapeutic use
Depression - prevention & control
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - prevention & control
Drug therapy
Female
Glycated Hemoglobin
Hormones
Humanities and Social Sciences
Humans
Insulin Resistance
Male
Medical personnel
Mental depression
Middle Aged
multidisciplinary
Prevention
Refugees
Science
Science (multidisciplinary)
Social services
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Summary:Depression and antidepressant medications increase risk for type 2 diabetes. Cambodian-Americans have exceedingly high rates of both depression and diabetes. This paper reports outcomes of a diabetes prevention trial for Cambodian-Americans with depression. Primary outcomes were HbA1c, insulin resistance and depressive symptoms. Participants were aged 35–75, Khmer speaking, at risk for diabetes, and met study criteria for likely depression by either (a) antidepressant medication and/or (b) prolonged elevated depressive symptoms. Participants were randomized to one of three community health worker (CHW) interventions: (1) lifestyle intervention called Eat, Walk, Sleep (EWS), (2) EWS plus medication therapy management sessions with a pharmacist/CHW team to resolve drug therapy problems (EWS + MTM), or, (3) social services (SS; control). Assessments were at baseline, post-treatment (12 months), and follow-up (15 months). The n = 188 participants were 78% female, average age of 55 years, half had a household income 
ISSN:2045-2322
DOI:10.1038/s41598-023-35738-9