Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer

The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals. Froz...

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Bibliographic Details
Published in:Infectious agents and cancer 2017-05, Vol.12 (1), p.31-31, Article 31
Main Authors: Fołtyn, Sylwia, Strycharz-Dudziak, Małgorzata, Drop, Bartłomiej, Boguszewska, Anastazja, Polz-Dacewicz, Małgorzata
Format: Article
Language:English
Subjects:
Alcohol
Antibodies
Antigens
Deoxyribonucleic acid
DNA
EBV antibodies
Enzyme-linked immunosorbent assay
Epstein-Barr virus
Gastric cancer
Gene expression
Head & neck cancer
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Infections
Laryngeal cancer
Larynx
LMP1
Lymphoma
Oropharyngeal cancer
Otolaryngology
Polymerase chain reaction
Throat cancer
Viral infections
Viruses
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Summary:The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals. Frozen tumor tissue fragments were tested using nested PCR assay for EBV DNA detection. Sera from all individuals were investigated using ELISA tests to detect the presence of VCA IgM and IgG, EBNA IgG, EA IgG. EBV DNA was detected in 52.7% of the patients (25% in controls). EBVCA were detected in 94.5%, EBNA in 96.4% and EA in 94.5% of patients. The significantly higher level of EA in the patients suggests EBV reactivation. The majority of patients (83%) were infected with wild-type EBV. Our study showed that this variant seems to be associated with oropharyngeal and laryngeal cancer in the Polish population.
ISSN:1750-9378
1750-9378
DOI:10.1186/s13027-017-0141-x