Venous Thromboembolism in Pregnancy: Challenges and Solutions

Venous thromboembolism (VTE) is a serious medical condition that can lead to severe morbidity and mortality, making it a significant public health concern. VTE is a multifactorial condition that results from the interaction of genetic, acquired, and environmental factors. Physiological changes durin...

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Bibliographic Details
Published in:Vascular health and risk management 2023-01, Vol.19, p.469-484
Main Authors: Varrias, Dimitrios, Spanos, Michail, Kokkinidis, Damianos G, Zoumpourlis, Panagiotis, Kalaitzopoulos, Dimitrios Rafail
Format: Article
Language:English
Subjects:
Anticoagulants (Medicine)
Anticoagulants - adverse effects
anticoagulation
Blood coagulation factors
Canada
Cesarean section
Female
Health aspects
Humans
Mortality
Pregnancy
Review
Risk Factors
Thromboembolism
thrombosis
venous embolism
Venous Thromboembolism - diagnosis
Venous Thromboembolism - drug therapy
Venous Thromboembolism - epidemiology
vte
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Summary:Venous thromboembolism (VTE) is a serious medical condition that can lead to severe morbidity and mortality, making it a significant public health concern. VTE is a multifactorial condition that results from the interaction of genetic, acquired, and environmental factors. Physiological changes during pregnancy increase the risk of VTE as they express Virchow's triad (increased coagulation factors, decreased fibrinolysis, trauma, and venous stasis). Moreover, pregnancy-related risk factors, such as advanced maternal age, obesity, multiple gestations, and cesarean delivery, further increase the risk of VTE. Managing VTE in pregnancy is challenging due to the complexity of balancing the risks and benefits of anticoagulant therapy for both the mother and the fetus. A multidisciplinary approach involving obstetricians, hematologists, and neonatologists, is necessary to ensure optimal outcomes for both the mother and baby. This review aims to discuss the current challenges associated with VTE in pregnancy and identify potential solutions for improving outcomes for pregnant women at risk for VTE.
ISSN:1178-2048
1176-6344
1178-2048
DOI:10.2147/VHRM.S404537