Identification of MIR600HG/hsa-miR-342-3p/ANLN network as a potential prognosis biomarker associated with lmmune infiltrates in pancreatic cancer

Pancreatic cancer is one of the tumors with the worst prognosis, causing serious harm to human health. The RNA network and immune response play an important role in tumor progression. While a systematic RNA network linked to the tumor immune response remains to be further explored in pancreatic canc...

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Bibliographic Details
Published in:Scientific reports 2023-09, Vol.13 (1), p.15919-15919, Article 15919
Main Authors: Qian, Baolin, Liu, Qi, Wang, Chaoqun, Lu, Shounan, Ke, Shanjia, Yin, Bing, Li, Xinglong, Yu, Hongjun, Wu, Yaohua, Ma, Yong
Format: Article
Language:English
Subjects:
631/114/2114
692/4020/1503/1712/1713
Biomarkers
Chemokines
Effector cells
Gene expression
Genomes
Humanities and Social Sciences
Humans
Immune response
Immunological memory
Infiltration
Lymphocytes T
Medical prognosis
Metastases
MicroRNAs - genetics
multidisciplinary
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - genetics
Prognosis
Ribonucleic acid
RNA
Science
Science (multidisciplinary)
Tumors
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Summary:Pancreatic cancer is one of the tumors with the worst prognosis, causing serious harm to human health. The RNA network and immune response play an important role in tumor progression. While a systematic RNA network linked to the tumor immune response remains to be further explored in pancreatic cancer. Based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, the MIR600HG/hsa-miR-342-3p/ANLN network was determined. WB and IHC were used to confirm the high expression of ANLN in pancreatic cancer. The prognostic model based on the RNA network could effectively predict the survival prognosis of patients. The analysis of immune infiltration showed that the MIR600HG/hsa-miR-342-3p/ANLN network altered the level of infiltration of T helper 2 (Th2) and effector memory T (Tem) cells. Furthermore, we found that the chemokines chemokine ligand (CCL) 5 and CCL14 may play a key role in immune cell infiltration mediated by the RNA network. In conclusion, this study constructed a prognostic model based on the MIR600HG/hsa-miR-342-3p/ANLN network and found that it may function in tumor immunity.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-43174-y