Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in a teaching hospital in Eastern India

Statement of the Problem: Healthcare workers (HCW) are the most vulnerable group for contracting SARS-CoV-2. Assessment of seroprevalence of SARS-CoV-2 antibodies among HCW, thus can provide important data on pathogen exposure, infectivity, and adherence to personal protective equipment (PPE). The p...

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Published in:Journal of family medicine and primary care 2021-08, Vol.10 (8), p.2974-2979
Main Authors: Mishra, Baijayantimala, Behera, Bijayini, Singh, Arvind, Mohapatra, Prasanta, Patro, Binod, Panigrahi, Manoj, Pillai, Jawahar, Barik, Sadanand, Mahapatra, Ashoka, Mohanty, Srujana, Hallur, Vinaykumar, Gupta, Kavita, Batmanabane, Gitanjali
Format: Article
Language:English
Subjects:
Antibodies
antibody
BCG
BCG vaccines
covid-19
Health aspects
healthcare worker
Medical personnel
Original
sars-cov-2
Viral antibodies
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Summary:Statement of the Problem: Healthcare workers (HCW) are the most vulnerable group for contracting SARS-CoV-2. Assessment of seroprevalence of SARS-CoV-2 antibodies among HCW, thus can provide important data on pathogen exposure, infectivity, and adherence to personal protective equipment (PPE). The present study aimed at assessing SARS-CoV-2 seroprevalence among HCW and exploring associations with demographics, category of exposure to COVID-19 patients, preventive measures taken and relation with COVID-19 symptoms. Method of Study: HCWs with a minimum gap 2 weeks from last duty were eligible to participate in the study. The enrolled HCW were categorized into high-risk and low-risk category based on work in COVID-19 areas. HCWs SARS-CoV-2 specific IgG and IgM antibodies were detected using rapid immunochromatography test. Results: Out of 821 randomly selected HCWs, either IgM or IgG antibody was detected in 32 HCWs (32/821, 3.9%). Only IgM antibodies were detected in 14 (1.7%), only IgG was detected in 9 (1.0%), and both IgM and IgG antibodies were present in 9 HCWs. Seropositivity was significantly higher in high-risk category (5.7% vs. 2.2.%), HCWs who ever had COVID-19 related symptoms in last 3 months (5.6% vs. 2.8%), and those who had earlier tested positive for SARS-CoV-2 with real-time reverse transcriptase PCR (36.6% vs. 3.5%). Seroprevalence was highest (6.9%) among housekeeping and sanitation staff. Conclusions: Overall, low seroprevalence of SARS-CoV-2 antibodies in our HCWs is an indicator of effective infection control practice. HCW posted in dedicated COVID ward need more stringent implementation of infection prevention measures.
ISSN:2249-4863
2278-7135
DOI:10.4103/jfmpc.jfmpc_2486_20