Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease

4-hydroxynonenal (HNE) is a lipid hydroperoxide end product formed from the oxidation of n-6 polyunsaturated fatty acids. The relative abundance of HNE within the vasculature is dependent not only on the rate of lipid peroxidation and HNE synthesis but also on the removal of HNE adducts by phase II...

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Bibliographic Details
Published in:Redox biology 2013-01, Vol.1 (1), p.319-331
Main Authors: Chapple, Sarah J, Cheng, Xinghua, Mann, Giovanni E
Format: Article
Language:English
Subjects:
4-hydroxynonenal
Aldehydes - metabolism
Endoplasmic Reticulum - metabolism
Endothelial cells
Endothelium, Vascular - cytology
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Health
Humans
Mitochondria - metabolism
Muscle, Smooth - cytology
Muscle, Smooth - metabolism
Muscle, Smooth - pathology
Nrf2
Oxidation-Reduction
Redox signaling
Review
Signal Transduction
Vascular biology
Vascular smooth muscle cells
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Summary:4-hydroxynonenal (HNE) is a lipid hydroperoxide end product formed from the oxidation of n-6 polyunsaturated fatty acids. The relative abundance of HNE within the vasculature is dependent not only on the rate of lipid peroxidation and HNE synthesis but also on the removal of HNE adducts by phase II metabolic pathways such as glutathione-S-transferases. Depending on its relative concentration, HNE can induce a range of hormetic effects in vascular endothelial and smooth muscle cells, including kinase activation, proliferation, induction of phase II enzymes and in high doses inactivation of enzymatic processes and apoptosis. HNE also plays an important role in the pathogenesis of vascular diseases such as atherosclerosis, diabetes, neurodegenerative disorders and in utero diseases such as pre-eclampsia. This review examines the known production, metabolism and consequences of HNE synthesis within vascular endothelial and smooth muscle cells, highlighting alterations in mitochondrial and endoplasmic reticulum function and their association with various vascular pathologies.
ISSN:2213-2317
2213-2317
DOI:10.1016/j.redox.2013.04.001