Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid...

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Bibliographic Details
Published in:Nature communications 2016-07, Vol.7 (1), p.12252-12252, Article 12252
Main Authors: Jin, Haibao, Jiao, Fang, Daily, Michael D., Chen, Yulin, Yan, Feng, Ding, Yan-Huai, Zhang, Xin, Robertson, Ellen J., Baer, Marcel D., Chen, Chun-Long
Format: Article
Language:English
Subjects:
119/118
639/638/541/966
639/638/549/977/974
639/925/357/1018
Chemistry
Crystallization
Humanities and Social Sciences
Lipids
MATERIALS SCIENCE
Membranes
multidisciplinary
Nanomaterials
Peptides
Science
Science (multidisciplinary)
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Summary:An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications. Biomimetic membranes can be used for various applications such as sensors and separations. Here, Chen et al . report the assembly of lipid-like peptoids into stable and self-repairing 2D membrane nanomaterials that change in thickness when under external stimuli.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms12252