Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila , and mice'

Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in...

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Bibliographic Details
Published in:eLife 2023-06, Vol.12
Main Authors: Li, Yutian, Sarma, Anish A, Lee, Iris T, Tan, Fayth Hui, Abrams, Michael J, Condiotte, Zevin J, Heithe, Martin, Raffiee, Misha, Dabiri, John O, Gold, David A, Goentoro, Lea
Format: Article
Language:English
Subjects:
Amino acids
Amputation
Anesthesia
Animals
appendage
Appendages
Carbon dioxide
Cnidaria
Drosophila
Evolutionary Biology
Experiments
Insects
Insulin
leucine
Mice
moon jellyfish
Mortality
Nutrients
Physiology
Protocol
regeneration
Scientific Correspondence
Scyphozoa - physiology
Stem Cells and Regenerative Medicine
Stress
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Summary:Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30-50% of treated flies showed response in our assay.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.85370