Gut Microbiome of Patients With Breast Cancer in Vietnam

Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with breast cancer. Stool samples were collected before chemoth...

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Bibliographic Details
Published in:JCO global oncology 2024-02, Vol.10 (10), p.e2300234
Main Authors: Nguyen, Sang M, Tran, Huong T T, Long, Jirong, Shrubsole, Martha J, Cai, Hui, Yang, Yaohua, Nguyen, Lan M, Nguyen, Giang H, Nguyen, Chu V, Ta, To V, Wu, Jie, Cai, Qiuyin, Zheng, Wei, Tran, Thuan V, Shu, Xiao-Ou
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Language:English
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Summary:Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with breast cancer. Stool samples were collected before chemotherapy, with 162 pre- and 194 postsurgery. The gut microbiome was measured by shotgun metagenomic sequencing. Associations of gut microbial diversity, taxa abundance, and gut microbiome health index (GMHI) with sociodemographic, clinical factors, and tumor characteristics were evaluated. Postsurgery samples were associated with significantly lower α- and β-diversities ( < .001) and showed significant differences in the abundance of 15% of 2,864 investigated taxa (false discovery rate [FDR]
ISSN:2687-8941
2687-8941
DOI:10.1200/GO.23.00234