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Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review
Malaria is an infectious disease caused by protozoan parasites of the genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, t...
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| Published in: | Marine drugs 2021-02, Vol.19 (3), p.134 |
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| creator | Aguiar, Anna Caroline Campos Parisi, Julia Risso Granito, Renata Neves de Sousa, Lorena Ramos Freitas Renno, Ana Cláudia Muniz Gazarini, Marcos Leoni |
| description | Malaria is an infectious disease caused by protozoan parasites of the
genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC
below 10 µM or 10 µg/mL against
culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. The structural features of active compounds selected in this review may be an interesting scaffold to inspire synthetic development of new antimalarials for selectively targeting parasite cell metabolism. |
| doi_str_mv | 10.3390/md19030134 |
| format | article |
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genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC
below 10 µM or 10 µg/mL against
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genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC
below 10 µM or 10 µg/mL against
culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Marine drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aguiar, Anna Caroline Campos</au><au>Parisi, Julia Risso</au><au>Granito, Renata Neves</au><au>de Sousa, Lorena Ramos Freitas</au><au>Renno, Ana Cláudia Muniz</au><au>Gazarini, Marcos Leoni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review</atitle><jtitle>Marine drugs</jtitle><addtitle>Mar Drugs</addtitle><date>2021-02-28</date><risdate>2021</risdate><volume>19</volume><issue>3</issue><spage>134</spage><pages>134-</pages><issn>1660-3397</issn><eissn>1660-3397</eissn><abstract>Malaria is an infectious disease caused by protozoan parasites of the
genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC
below 10 µM or 10 µg/mL against
culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. The structural features of active compounds selected in this review may be an interesting scaffold to inspire synthetic development of new antimalarials for selectively targeting parasite cell metabolism.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33670878</pmid><doi>10.3390/md19030134</doi><orcidid>https://orcid.org/0000-0002-3882-6831</orcidid><orcidid>https://orcid.org/0000-0002-2094-3845</orcidid><orcidid>https://orcid.org/0000-0002-4325-0638</orcidid><orcidid>https://orcid.org/0000-0002-2506-8365</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Marine drugs, 2021-02, Vol.19 (3), p.134 |
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| subjects | Animals antimalarial Antimalarials - administration & dosage Antimalarials - isolation & purification Antimalarials - pharmacology Aquatic insects Artemisinin Bioactive compounds Biodiversity Cell culture Defence mechanisms Drug Development Drug Resistance, Multiple Erythrocytes Glycosphingolipids Human diseases Humans Infectious diseases Inhibitory Concentration 50 Literature reviews Malaria Malaria, Falciparum - drug therapy Marine invertebrates Marine organisms Metabolism Metabolites Mosquitoes Multidrug resistance Mutation Natural products Parasites Plasmodium Plasmodium falciparum - drug effects Polyketides Porifera - metabolism Protozoa resistance Review Secondary Metabolism Secondary metabolites sponge Sponges Systematic review Terpenes Vector-borne diseases |
| title | Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review |
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