Implications of deduplication on the detection rates of multidrug-resistant organism (MDRO) in various specimens: insights from the hospital infection surveillance program

• Published in: Antimicrobial resistance & infection control 2024-05, Vol.13 (1), p.54-54, Article 54
• Main Authors: Li, Zhanjie, Zhu, Dan, Ma, Xiaoju, Zang, Feng, Zhang, Weihong, Luo, Can, Zhu, Chuanlong, Chen, Wensen, Zhu, Ping
• Format: Article
• Language: English
• Subjects: Acinetobacter baumannii - drug effects; Acinetobacter baumannii - genetics; Acinetobacter baumannii - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Bacterial pneumonia; Bronchoalveolar Lavage Fluid - microbiology; Carbapenems - pharmacology; Cross Infection - epidemiology; Cross Infection - microbiology; Deduplicate; Detection rates; Different specimens; Drug resistance in microorganisms; Drug Resistance, Multiple, Bacterial; Epidemiological Monitoring; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; Escherichia coli - isolation & purification; Health aspects; Hospital patients; Hospitals; Humans; Implications; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - isolation & purification; MDRO; Medical research; Medicine, Experimental; Methicillin; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - isolation & purification; Pneumonia; Prevention; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - isolation & purification; Sputum - microbiology; Staphylococcus aureus infections
• ISSN: 2047-2994; 2047-2994
• DOI: 10.1186/s13756-024-01408-2

Currently, different guidelines recommend using different methods to determine whether deduplication is necessary when determining the detection rates of multidrug-resistant organisms (MDROs). However, few studies have investigated the effect of deduplication on MDRO monitoring data. In this study, we aimed to investigate the influence of deduplication on the detection rates of MDROs in different specimens to assess its impact on infection surveillance outcomes. Samples were collected from hospitalized patients admitted between January 2022 and December 2022; four types of specimens were collected from key monitored MDROs, including sputum samples, urine samples, blood samples, and bronchoalveolar lavage fluid (BALF) samples. In this study, we compared and analysed the detection rates of carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Escherichia coli (CRECO), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and methicillin-resistant Staphylococcus aureus (MRSA) under two conditions: with and without deduplication. When all specimens were included, the detection rates of CRKP, CRAB, CRPA, and MRSA without deduplication (33.52%, 77.24%, 44.56%, and 56.58%, respectively) were significantly greater than those with deduplication (24.78%, 66.25%, 36.24%, and 50.83%, respectively) (all P