Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases

Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenclature of pericytes and other perivascular cell ty...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-04, Vol.10 (4), p.890
Main Authors: Bohannon, Diana G, Long, Danielle, Kim, Woong-Ki
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biology
Blood-brain barrier
Brain research
endothelial cell
Growth factors
Homeostasis
Investigations
laminin
Low density lipoprotein receptors
Membrane permeability
Microscopy
multiple sclerosis
Neurological diseases
pericyte
Pericytes
Review
Roles
Smooth muscle
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Summary:Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenclature of pericytes and other perivascular cell types. In addition, pericyte heterogeneity and mouse-human species differences have contributed to confusion. Herein we summarize our present knowledge on the identification of pericytes and pericyte subsets in humans, primarily focusing on recent findings in humans and nonhuman primates. Precise identification and definition of pericytes and pericyte subsets in humans may help us to better understand pericyte biology and develop new therapeutic approaches specifically targeting disease-associated pericyte subsets.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10040890