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Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases

Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenclature of pericytes and other perivascular cell ty...

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Published in:	Cells (Basel, Switzerland) Switzerland), 2021-04, Vol.10 (4), p.890
Main Authors:	Bohannon, Diana G, Long, Danielle, Kim, Woong-Ki
Format:	Article
Language:	English
Subjects:	Alzheimer's disease Biology Blood-brain barrier Brain research endothelial cell Growth factors Homeostasis Investigations laminin Low density lipoprotein receptors Membrane permeability Microscopy multiple sclerosis Neurological diseases pericyte Pericytes Review Roles Smooth muscle
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description	Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenclature of pericytes and other perivascular cell types. In addition, pericyte heterogeneity and mouse-human species differences have contributed to confusion. Herein we summarize our present knowledge on the identification of pericytes and pericyte subsets in humans, primarily focusing on recent findings in humans and nonhuman primates. Precise identification and definition of pericytes and pericyte subsets in humans may help us to better understand pericyte biology and develop new therapeutic approaches specifically targeting disease-associated pericyte subsets.
doi_str_mv	10.3390/cells10040890
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subjects	Alzheimer's disease Biology Blood-brain barrier Brain research endothelial cell Growth factors Homeostasis Investigations laminin Low density lipoprotein receptors Membrane permeability Microscopy multiple sclerosis Neurological diseases pericyte Pericytes Review Roles Smooth muscle
title	Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases
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