Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives

Heart failure (HF) is a progressively deteriorating medical condition that significantly reduces both the patients' life expectancy and quality of life. Even though real progress was made in the past decades in the discovery of novel pharmacological treatments for HF, the prevention of prematur...

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Published in:Pharmaceutics 2022-09, Vol.14 (9), p.1964
Main Authors: Popa, Irene Paula, Haba, Mihai Ștefan Cristian, Mărănducă, Minela Aida, Tănase, Daniela Maria, Șerban, Dragomir N, Șerban, Lăcrămioara Ionela, Iliescu, Radu, Tudorancea, Ionuț
Format: Article
Language:English
Subjects:
angiotensin receptor–neprilysin inhibitor
autonomic modulation
cardiac myosin activation
Cardiac output
Cardiology
Complications and side effects
Diabetes
Drug therapy
Ejection fraction
Glucose
Health aspects
Heart attacks
Heart failure
Hospitalization
Measurement
Medical prognosis
Mortality
Peptides
Prognosis
Quality of life
Review
sodium-glucose co-transporter-2 inhibitors
soluble guanylate cyclase activator
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Summary:Heart failure (HF) is a progressively deteriorating medical condition that significantly reduces both the patients' life expectancy and quality of life. Even though real progress was made in the past decades in the discovery of novel pharmacological treatments for HF, the prevention of premature deaths has only been marginally alleviated. Despite the availability of a plethora of pharmaceutical approaches, proper management of HF is still challenging. Thus, a myriad of experimental and clinical studies focusing on the discovery of new and provocative underlying mechanisms of HF physiopathology pave the way for the development of novel HF therapeutic approaches. Furthermore, recent technological advances made possible the development of various interventional techniques and device-based approaches for the treatment of HF. Since many of these modern approaches interfere with various well-known pathological mechanisms in HF, they have a real ability to complement and or increase the efficiency of existing medications and thus improve the prognosis and survival rate of HF patients. Their promising and encouraging results reported to date compel the extension of heart failure treatment beyond the classical view. The aim of this review was to summarize modern approaches, new perspectives, and future directions for the treatment of HF.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14091964