Understanding the early host immune response against Mycobacterium tuberculosis

Generation of immune response is a crucial activity of host defense against any microbial attack. When facultative organism Mycobacterium tuberculosis (MTB) invades its host, various pathways are activated in the host to mount immune responses against invading pathogen for nullifying its actions. Du...

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Bibliographic Details
Published in:Central-European journal of immunology 2020-01, Vol.45 (1), p.99-103
Main Author: Jee, Babban
Format: Article
Language:English
Subjects:
Chemokines
Cytokines
Granuloma
host
Host-pathogen interactions
immune evasion
Immune response
Mycobacterium tuberculosis
Pathogens
Phagocytosis
Review Paper
Tuberculosis
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Summary:Generation of immune response is a crucial activity of host defense against any microbial attack. When facultative organism Mycobacterium tuberculosis (MTB) invades its host, various pathways are activated in the host to mount immune responses against invading pathogen for nullifying its actions. During this host-pathogen interaction, interplay of complex network of cytokines and chemokines, initiation of phagocytosis, and formation of granuloma play an important role in containing MTB infections at host side. Simultaneously, MTB also evolves a plethora of specialized mechanisms to evade the host's killing cascades on other side, and during this bilateral cross-talk, many mycobacterial products play crucial role in survival of MTB inside the host. Hence, a better understanding of these phenomena is necessary not only for getting clear picture of pathogenesis of MTB, but also for developing effective, preventive, and therapeutic modalities against the pathogen. With some suggestions on future work, an insight into diversity of immune response of host against MTB was provided in the present review.
ISSN:1426-3912
1644-4124
DOI:10.5114/ceji.2020.94711