Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography

The vascular hypothesis of systemic sclerosis (SSc) would predict microvascular alterations should also affect anatomical regions like ocular microvasculature. The objective of this study was to evaluate retinal and choriocapillary vessel density (VD) in patients with definite SSc and very early dis...

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Bibliographic Details
Published in:Scientific reports 2022-06, Vol.12 (1), p.10990-10990, Article 10990
Main Authors: Mihailovic, Nataša, Lahme, Larissa, Braasch, Sonja, Rosenberger, Friederike, Eter, Nicole, Ehrchen, Jan, Alnawaiseh, Maged
Format: Article
Language:English
Subjects:
692/4023
692/699/3161
Angiography
Correlation analysis
Correlation coefficient
Humanities and Social Sciences
Medical imaging
Microvasculature
multidisciplinary
Perfusion
Science
Science (multidisciplinary)
Scleroderma
Sexually transmitted diseases
STD
Systemic sclerosis
Tomography
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Summary:The vascular hypothesis of systemic sclerosis (SSc) would predict microvascular alterations should also affect anatomical regions like ocular microvasculature. The objective of this study was to evaluate retinal and choriocapillary vessel density (VD) in patients with definite SSc and very early disease of systemic sclerosis (VEDOSS) using optical coherence tomography angiography (OCTA). 22 eyes of 22 patients and 22 eyes of 22 healthy subjects were included in this study. Patients were classified into patients with definite SSc and patients with VEDOSS. VD data of the superficial OCT angiogram (OCTA-SCP), deep OCT angiogram (OCTA-DCP) and choriocapillaris (OCTA-CC) were analysed. VD in the OCTA-SCP and OCTA-CC was lower in patients with SSc (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-14377-6