Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling

Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL's role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions remain unresolved. Herein, we present the recent a...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2024-11, Vol.13 (22), p.1870
Main Authors: Wang, Lei, Zhu, Rui, Wen, Zehua, Fan, Hua-Jun Shawn, Norwood-Jackson, Teresa, Jathan, Danielle, Lee, Ho-Jin
Format: Article
Language:English
Subjects:
AlphaFold
Amino acids
Animals
cancer
Cell growth
Dishevelled
Dishevelled protein
Dishevelled Proteins - metabolism
Enzymes
Gene expression
Humans
Kinases
Ligands
mechanism
Phosphorylation
post-translation
Protein Domains
Proteins
Review
Signal transduction
Structure-function relationships
Transcription factors
Wnt
Wnt protein
Wnt Signaling Pathway
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL's role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions remain unresolved. Herein, we present the recent advances and perspectives on how DVL regulates signaling. The experimentally determined conserved domain structures of DVL in conjunction with AlphaFold-predicted structures are used to understand the DVL's role in Wnt signaling regulation. We also summarize the role of DVL in various diseases and provide insights into further directions for research on the DVL-mediated signaling mechanisms. These findings underscore the importance of DVL as a pharmaceutical target or biological marker in diseases, offering exciting potential for future biomedical applications.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13221870