Distinct dynamics of the nucleolus in response to nutrient availability and during development in the rice blast fungus

The nucleolus is a dynamic subnuclear structure that is involved in many fundamental processes of the nucleus. In higher eukaryotic cells, the size and shape of nucleoli correlate with nucleolar activities. For fungi, knowledge of the nucleolus and its functions is primarily gleaned from budding yea...

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Bibliographic Details
Published in:mBio 2023-10, Vol.14 (5), p.e0184423-e0184423
Main Authors: Cho, Eunbyeol, Lee, Song Hee, Dean, Ralph A, Jeon, Junhyun
Format: Article
Language:English
Subjects:
filamentous fungi
fungal development
Mycology
nucleolus
nutrient availability
Observation
rice blast
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Summary:The nucleolus is a dynamic subnuclear structure that is involved in many fundamental processes of the nucleus. In higher eukaryotic cells, the size and shape of nucleoli correlate with nucleolar activities. For fungi, knowledge of the nucleolus and its functions is primarily gleaned from budding yeast. Whether such correlation is conserved and how nucleolar functions are regulated in filamentous fungi including important human and crop pathogens are largely unknown. Our observations reveal that the dynamics of nucleolus in a model plant pathogenic fungus, is distinct from those of animal and yeast nucleoli under low nutrient availability and during pathogenic development. Our data not only provide new insight into the nucleoli in filamentous fungi but also highlight the need for investigating how nucleolar dynamics is regulated in comparison to other eukaryotes.
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.01844-23