Chemical Constituents from the Whole Plant of Cuscuta reflexa

Two new 2 H -pyran-2-one glucosides, cuscutarosides A ( 1 ) and B ( 2 ), and one new steroidal glucoside, 7 β -methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ), together with 12 known compounds ( 4 – 15 ) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Mya...

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Bibliographic Details
Published in:Natural products and bioprospecting 2020-10, Vol.10 (5), p.337-344
Main Authors: Aung, Tin Thu Thu, Xia, Meng-Yuan, Hein, Pyae Phyo, Tang, Rong, Zhang, Dong-Dong, Yang, Jun, Yang, Xue-Fei, Hu, Dong-Bao, Wang, Yue-Hu
Format: Article
Language:English
Subjects:
2H-pyran-2-one glucosides
Biomedical and Life Sciences
Bioorganic Chemistry
Cuscuta reflexa
Food Science
Life Sciences
Medicinal Chemistry
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Platelet aggregation
Porcine pancreatic lipase
Steroidal glucosides
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Summary:Two new 2 H -pyran-2-one glucosides, cuscutarosides A ( 1 ) and B ( 2 ), and one new steroidal glucoside, 7 β -methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ), together with 12 known compounds ( 4 – 15 ) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7 β -Methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ) showed weak PPL inhibitory activity. Cuscutaroside A ( 1 ), its acetylated derivative ( 1a ), and scrophenoside B ( 8 ) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-020-00265-x