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Chemical Constituents from the Whole Plant of Cuscuta reflexa

Two new 2 H -pyran-2-one glucosides, cuscutarosides A ( 1 ) and B ( 2 ), and one new steroidal glucoside, 7 β -methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ), together with 12 known compounds ( 4 – 15 ) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Mya...

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Published in:	Natural products and bioprospecting 2020-10, Vol.10 (5), p.337-344
Main Authors:	Aung, Tin Thu Thu, Xia, Meng-Yuan, Hein, Pyae Phyo, Tang, Rong, Zhang, Dong-Dong, Yang, Jun, Yang, Xue-Fei, Hu, Dong-Bao, Wang, Yue-Hu
Format:	Article
Language:	English
Subjects:	2H-pyran-2-one glucosides Biomedical and Life Sciences Bioorganic Chemistry Cuscuta reflexa Food Science Life Sciences Medicinal Chemistry Original Original Article Pharmacology/Toxicology Plant Biochemistry Plant Sciences Platelet aggregation Porcine pancreatic lipase Steroidal glucosides
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creator	Aung, Tin Thu Thu Xia, Meng-Yuan Hein, Pyae Phyo Tang, Rong Zhang, Dong-Dong Yang, Jun Yang, Xue-Fei Hu, Dong-Bao Wang, Yue-Hu
description	Two new 2 H -pyran-2-one glucosides, cuscutarosides A ( 1 ) and B ( 2 ), and one new steroidal glucoside, 7 β -methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ), together with 12 known compounds ( 4 – 15 ) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7 β -Methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ) showed weak PPL inhibitory activity. Cuscutaroside A ( 1 ), its acetylated derivative ( 1a ), and scrophenoside B ( 8 ) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. Graphic Abstract
doi_str_mv	10.1007/s13659-020-00265-x
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The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7 β -Methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ) showed weak PPL inhibitory activity. Cuscutaroside A ( 1 ), its acetylated derivative ( 1a ), and scrophenoside B ( 8 ) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. 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Prod. Bioprospect</addtitle><addtitle>Nat Prod Bioprospect</addtitle><description>Two new 2 H -pyran-2-one glucosides, cuscutarosides A ( 1 ) and B ( 2 ), and one new steroidal glucoside, 7 β -methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ), together with 12 known compounds ( 4 – 15 ) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7 β -Methoxy- β -sitosterol 3- O - β -glucopyranoside ( 3 ) showed weak PPL inhibitory activity. Cuscutaroside A ( 1 ), its acetylated derivative ( 1a ), and scrophenoside B ( 8 ) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. 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subjects	2H-pyran-2-one glucosides Biomedical and Life Sciences Bioorganic Chemistry Cuscuta reflexa Food Science Life Sciences Medicinal Chemistry Original Original Article Pharmacology/Toxicology Plant Biochemistry Plant Sciences Platelet aggregation Porcine pancreatic lipase Steroidal glucosides
title	Chemical Constituents from the Whole Plant of Cuscuta reflexa
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