A Simple Assay to Assess Salmonella Typhimurium Impact on Performance and Immune Status of Growing Pigs after Different Inoculation Doses

Typhimurium is the most frequent serovar in pigs and causes infections in humans. However, the dosage used for experimentation is not well defined. The present study aimed to evaluate a dosage for oral inoculation with Typhimurium to assess immunological and growth performance alterations in pigs. G...

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Bibliographic Details
Published in:Microorganisms (Basel) 2023-02, Vol.11 (2), p.446
Main Authors: Alves da Cunha Valini, Graziela, Arnaut, Pedro Righetti, Barbosa, Larissa Gonçalves, de Azevedo, Paulo Henrique Amadeu, Melo, Antonio Diego Brandão, Marçal, Danilo Alves, Campos, Paulo Henrique Reis Furtado, Hauschild, Luciano
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Body temperature
Body weight
Colonies
Dosage
Experimentation
Feces
Feed conversion
Feed efficiency
Feeds
growth
Growth rate
Hematocrit
Hemoglobin
Hogs
Immune status
Immune system
immunologic response
Immunology
Inoculation
Physiology
Rectum
Salmonella
Salmonella Typhimurium
sanitary challenge
Swine
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Summary:Typhimurium is the most frequent serovar in pigs and causes infections in humans. However, the dosage used for experimentation is not well defined. The present study aimed to evaluate a dosage for oral inoculation with Typhimurium to assess immunological and growth performance alterations in pigs. Gilts were randomly allocated into one of three experimental treatments: no Typhimurium inoculation (Basal), or oral inoculation of 1 × 10 or 1.5 × 10 colony-forming units of Typhimurium. Growth rate, rectal temperature, and fecal shedding were recorded. Blood samples were taken. Inoculated pigs shed the bacteria for up to 7 days, but no differences were observed between the groups. No differences were observed in rectal temperature, body weight, or average daily feed intake. However, reductions in average daily gain (-17 and -22%) and feed efficiency (-14 and -20%) were observed in pigs inoculated with 1 × 10 and 1.5 × 10 colony-forming units, respectively. The hemoglobin and hematocrit concentrations increased in challenged pigs compared to Basal pigs. The oral dosage of 1.5 × 10 colony-forming units of Typhimurium is suitable for activating the immune system of pigs and assessing the impact of on pig performance.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms11020446