Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?

Autologous nerve grafts are used to bridge peripheral nerve defects. Limited sources and donor site morbidity are the major problems with peripheral nerve grafts. Although various types of autologous grafts such as arteries, veins and muscles have been recommended, an ideal conduit has not yet been...

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Bibliographic Details
Published in:Balkan medical journal 2017-05, Vol.34 (3), p.246-254
Main Authors: Arda, Mehmet S, Koçman, Emre A, Özkara, Emre, Söztutar, Erdem, Özatik, Orhan, Köse, Aydan, Çetin, Cengiz
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Axons - physiology
Care and treatment
Case studies
conduits
Female
Injuries
Intestinal mucosa
Intestine, Small - innervation
Intestine, Small - surgery
Nerve Regeneration - physiology
Nerves, Peripheral
Nervous system
Neurosurgical Procedures - methods
Original
Peripheral nerve injury
Peripheral Nerves - growth & development
Peripheral Nerves - surgery
Rats
Rats, Sprague-Dawley - growth & development
Rats, Sprague-Dawley - surgery
Recovery of Function
Regeneration
Sciatic Nerve - growth & development
Sciatic Nerve - surgery
small intestine
Tıp
Transplantation, Autologous - methods
Transplants - surgery
Turkey
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Summary:Autologous nerve grafts are used to bridge peripheral nerve defects. Limited sources and donor site morbidity are the major problems with peripheral nerve grafts. Although various types of autologous grafts such as arteries, veins and muscles have been recommended, an ideal conduit has not yet been described. To investigate the effectiveness of a small intestinal conduit for peripheral nerve defects. Animal experimentation. Twenty-one rats were divided into three groups (n=7). Following anaesthesia, sciatic nerve exploration was performed in the Sham group. The 10 mm nerve gap was bridged with a 15 mm ileal segment in the small intestinal conduit group and the defect was replaced with orthotopic nerve in autologous nerve graft group. The functional recovery was tested monthly by walking-track analysis and the sciatic functional index. Histological evaluation was performed on the 12th week. Sciatic functional index tests are better in autologous nerve graft group (-55.09±6.35); however, during follow-up, progress in sciatic functional index was demonstrated, along with axonal regeneration and innervation of target muscles in the small intestinal conduit group (-76.36±12.08) (p
ISSN:2146-3123
2146-3131
DOI:10.4274/balkanmedj.2015.1601