The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Background. The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive. Methods. We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with p...

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Bibliographic Details
Published in:Journal of diabetes research 2015-01, Vol.2015 (2015), p.1-10
Main Authors: Li, Na, Fathzadeh, Mohsen, Srivastava, Roshni, Song, Kangxing, Wang, Shuxia, Mani, Arya
Format: Article
Language:English
Subjects:
Alleles
Atherosclerosis
Bias
Cardiovascular disease
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Fasting
Fasting - blood
Genetic Predisposition to Disease
Gestational age
Humans
Lipids
Meta-analysis
Metabolic syndrome
Plasma
Polymorphism
Population
Review
Software
Studies
Transcription Factor 7-Like 2 Protein - genetics
Transcription factors
Triglycerides - blood
Women
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Summary:Background. The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive. Methods. We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized. Results. 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = −0.04, 95% CI (−0.08, 0.00), P = 0.048, Pheterogeneity = 0.47; recessive model: SMD = −0.10, 95% CI (−0.18, −0.02), P = 0.01, Pheterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects. Conclusions. Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.
ISSN:2314-6745
2314-6753
DOI:10.1155/2015/468627