Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms i...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2023-03, Vol.13 (7), p.1140
Main Authors: Gareev, Kamil, Tagaeva, Ruslana, Bobkov, Danila, Yudintceva, Natalia, Goncharova, Daria, Combs, Stephanie E, Ten, Artem, Samochernych, Konstantin, Shevtsov, Maxim
Format: Article
Language:English
Subjects:
Amino acids
Blood
blood–tissue barrier
blood–tumor barrier
Cavitation
cell-penetrating peptide
Chemical agents
Clinical trials
Efflux
Electroporation
Energy
Health aspects
histohematic barrier
Hydrogen bonds
Lipids
Magnetic fields
Nanoparticles
Peptides
Permeability
Physiological aspects
Physiology
Precision medicine
Proteins
Review
Tight junctions
Translocation
tumor theranostics
Tumors
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Summary:Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood-tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood-tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano13071140