Protective effects of ethanolic extract from the red algae Amansia multifida on experimental inflammation, nociception and seizure experimental models

This study aimed to investigate the EEAm effect in mice models of nociception, inflammation and in behavioral tests evaluating the central nervous system. EEAm had inhibitory effects in the following tests: acetic acid-induced writhing (78%); formalin (62% - inflammatory phase); open field (46%). EE...

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Bibliographic Details
Published in:Acta scientiarum. Biological sciences 2016, Vol.38 (4), p.465
Main Authors: Aragão, Gislei Frota, Nonato, Dayanne Terra Tenório, Ponta, Edson Lopes da, Sales, Jonathan Rodrigues, Alencar, Daniel Barroso, Sampaio, Silvana Saker, Camelo Chaves, Edna Maria, Assreuy, Ana Maria Sampaio
Format: Article
Language:English
Subjects:
acute inflammatory process
Algae
antinociception
Convulsions & seizures
epilepsy
Herbal medicine
Inflammation
Laboratory animals
Nervous system
red seaweed
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Summary:This study aimed to investigate the EEAm effect in mice models of nociception, inflammation and in behavioral tests evaluating the central nervous system. EEAm had inhibitory effects in the following tests: acetic acid-induced writhing (78%); formalin (62% - inflammatory phase); open field (46%). EEAm increased the nociceptive latency (56%) in tail flick test and increased the death-latency by 36% in the pentylenetetrazole-induced seizure model. Moreover, EEAm inhibited paw edema (82%) and peritonitis (45%) induced by carrageenan. In conclusion, EEAm presents antinociceptive, anti-inflammatory and anticonvulsant effects involving peripheral and central-acting mechanisms in mice. 
ISSN:1679-9283
1807-863X
DOI:10.4025/actascibiolsci.v38i4.32361