To Evaluate Efficacy of Pregabalin for the Prevention of Etomidate-induced Myoclonus: A Prospective, Randomized, Placebo-controlled, Double-blind Study

• Published in: Apollo medicine 2021-09, Vol.18 (3), p.154-157
• Main Authors: Srivastava, Vinit Kumar, Agrawal, Sanjay, Kumar, Sanjay, Pandey, Ambikesh, Garewal, Shweta, Shree, Pooja
• Format: Article
• Language: English
• Subjects: etomidate; myoclonus; postoperative sedation; pregabalin
• ISSN: 0976-0016; 2213-3682
• DOI: 10.4103/am.am_8_21

Context: The incidence of myoclonus after etomidate induction is 50%–80%. The present study evaluated the efficacy of oral pregabalin for the prevention of etomidate-induced myoclonus. Settings and Design: A prospective, randomized, placebo-controlled, double-blind study. Subjects and Methods: Seventy-four patients of the American Society of Anesthesiologists physical status Grade I or II scheduled for elective surgery under anesthesia were recruited. Following exclusion, 66 patients were randomized into two groups. In Group P patients received pregabalin 150 mg orally 1 h before induction of anesthesia and in Group C patients received placebo tablet. The primary outcome was the incidence and severity of myoclonus. The secondary outcome was the postoperative sedation level. Results: The incidence and severity of myoclonus were significantly decreased in Group P compared with Group C (P < 0.05). The postoperative sedation score was significantly higher in Group P compared to Group C (P > 0.05). Conclusion: Pretreatment with pregabalin 150 mg orally reduced the incidence and severity of etomidate-induced myoclonus however incidence of sedation was more.