Infection Load and Prevalence of Novel Viruses Identified from the Bank Vole Do Not Associate with Exposure to Environmental Radioactivity

Bank voles ( ) are host to many zoonotic viruses. As bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated DNA repair activity, we predicted an association between virome composition and exposure to radionuclides. To test thi...

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Bibliographic Details
Published in:Viruses 2019-12, Vol.12 (1), p.44
Main Authors: Kesäniemi, Jenni, Lavrinienko, Anton, Tukalenko, Eugene, Mappes, Tapio, Watts, Phillip C, Jurvansuu, Jaana
Format: Article
Language:English
Subjects:
adeno-associated virus
Animals
Apoptosis
arterivirus
Arvicolinae - virology
bank vole
Disseminated infection
DNA repair
Environment
environmental radiation
Female
Genetic testing
High-Throughput Nucleotide Sequencing
Immunosuppression
Male
mosavirus
next-generation sequencing
Nuclear Power Plants
Phylogenetics
Plasma
plasma viromes
Prevalence
Proteins
Radiation
Radioactive Pollutants
Radioactivity
Radioisotopes
Rodents
Viral Load
Viruses
Viruses - classification
Viruses - isolation & purification
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Summary:Bank voles ( ) are host to many zoonotic viruses. As bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated DNA repair activity, we predicted an association between virome composition and exposure to radionuclides. To test this hypothesis, we studied the bank vole virome in samples of plasma derived from animals inhabiting areas of Ukraine (contaminated areas surrounding the former nuclear power plant at Chernobyl, and uncontaminated areas close to Kyiv) that differed in level of environmental radiation contamination. We discovered four strains of hepacivirus and four new virus sequences: two adeno-associated viruses, an arterivirus, and a mosavirus. However, viral prevalence and viral load, and the ability to cause a systemic infection, was not dependent on the level of environmental radiation.
ISSN:1999-4915
1999-4915
DOI:10.3390/v12010044