The impact of variants and vaccination on the mortality and resource utilization of hospitalized patients with COVID-19

COVID-19 outcomes among hospitalized patients may have changed due to new variants, therapies and vaccine availability. We assessed outcomes of adults hospitalized with COVID-19 from March 2020-February 2022. Data were retrieved from electronic health medical records of adult COVID-19 patients hospi...

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Published in:BMC infectious diseases 2022-08, Vol.22 (1), p.702-11, Article 702
Main Authors: Stepanova, Maria, Lam, Brian, Younossi, Elena, Felix, Sean, Ziayee, Mariam, Price, Jillian, Pham, Huong, de Avila, Leyla, Terra, Kathy, Austin, Patrick, Jeffers, Thomas, Escheik, Carey, Golabi, Pegah, Cable, Rebecca, Srishord, Manirath, Venkatesan, Chapy, Henry, Linda, Gerber, Lynn, Younossi, Zobair M
Format: Article
Language:English
Subjects:
Adult
Analysis
Body mass index
Care and treatment
Casualties
Community-Acquired Infections
Comorbidity
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
Demographics
Demography
Emerging diseases
Health care
Health services utilization
Healthcare utilization
Hospital patients
Hospitalization
Humans
Immunization
Infections
Medical care
Medical records
Mortality
Multimorbidity
Observational studies
Oxygen saturation
Pandemics
Patients
Pneumococcal Vaccines
Pneumonia
Public health
Resource utilization
Risk analysis
Risk factors
Severe acute respiratory syndrome coronavirus 2
Utilization
Vaccination
Ventilators
Viral diseases
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Summary:COVID-19 outcomes among hospitalized patients may have changed due to new variants, therapies and vaccine availability. We assessed outcomes of adults hospitalized with COVID-19 from March 2020-February 2022. Data were retrieved from electronic health medical records of adult COVID-19 patients hospitalized in a large community health system. Duration was split into March 2020-June 2021 (pre-Delta period), July-November 2021 (Delta period), and December 2021-February 2022 (Omicron period). Of included patients (n = 9582), 75% were admitted during pre-Delta, 9% during Delta, 16% during Omicron period. The COVID-positive inpatients were oldest during Omicron period but had lowest rates of COVID pneumonia and resource utilization (p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-022-07657-z