The potential role of hydrogen sulfide in cancer cell apoptosis

For a long time, hydrogen sulfide (H 2 S) has been considered a toxic compound, but recent studies have found that H 2 S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H 2 S mediates...

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Bibliographic Details
Published in:Cell death discovery 2024-03, Vol.10 (1), p.114-15, Article 114
Main Authors: Gao, Wei, Liu, Ya-Fang, Zhang, Yan-Xia, Wang, Yan, Jin, Yu-Qing, Yuan, Hang, Liang, Xiao-Yi, Ji, Xin-Ying, Jiang, Qi-Ying, Wu, Dong-Dong
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
631/67/2327
631/80/82
AKT protein
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cancer
Cancer therapies
Cell Biology
Cell cycle
Cell Cycle Analysis
Cell death
Cytoplasm
DNA damage
Enzymes
Homocysteine
Hydrogen
Hydrogen sulfide
Kinases
Life Sciences
MAP kinase
Metabolism
Mitochondria
Physiology
Proteins
Respiration
Review
Review Article
Signal transduction
Stem Cells
TOR protein
Tumorigenesis
Tumors
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Summary:For a long time, hydrogen sulfide (H 2 S) has been considered a toxic compound, but recent studies have found that H 2 S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H 2 S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H 2 S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H 2 S in cancer cell apoptosis in mammals are summarized.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-024-01868-w