Graphene Quantum Dots' Surface Chemistry Modulates the Sensitivity of Glioblastoma Cells to Chemotherapeutics

Recent evidence has shown that graphene quantum dots (GQDs) are capable of crossing the blood-brain barrier, the barrier that reduces cancer therapy efficacy. Here, we tested three alternative GQDs' surface chemistries on two neural lineages (glioblastoma cells and mouse cortical neurons). We s...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-08, Vol.21 (17), p.6301
Main Authors: Perini, Giordano, Palmieri, Valentina, Ciasca, Gabriele, D'Ascenzo, Marcello, Gervasoni, Jacopo, Primiano, Aniello, Rinaldi, Monica, Fioretti, Daniela, Prampolini, Chiara, Tiberio, Federica, Lattanzi, Wanda, Parolini, Ornella, De Spirito, Marco, Papi, Massimiliano
Format: Article
Language:English
Subjects:
Acids
Animals
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacology
Apoptosis
Biocompatibility
Blood-brain barrier
Brain cancer
cancer treatment
Cell membranes
Cell Proliferation
Cytotoxicity
Doxorubicin
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug delivery systems
Embryo, Mammalian - cytology
Embryo, Mammalian - drug effects
Glioblastoma
Glioblastoma - drug therapy
Glioblastoma - pathology
Glioblastoma cells
Graphene
graphene quantum dots
Graphite - chemistry
Humans
Investigations
Membrane permeability
Mice
Mice, Inbred C57BL
nanomedicine
Neurons
Neurons - cytology
Neurons - drug effects
Quantum Dots
Stem cells
Surface chemistry
Synergistic effect
synergistic therapy
Tumor cells
Tumor Cells, Cultured
Vitamin B
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Summary:Recent evidence has shown that graphene quantum dots (GQDs) are capable of crossing the blood-brain barrier, the barrier that reduces cancer therapy efficacy. Here, we tested three alternative GQDs' surface chemistries on two neural lineages (glioblastoma cells and mouse cortical neurons). We showed that surface chemistry modulates GQDs' biocompatibility. When used in combination with the chemotherapeutic drug doxorubicin, GDQs exerted a synergistic effect on tumor cells, but not on neurons. This appears to be mediated by the modification of membrane permeability induced by the surface of GQDs. Our findings highlight that GQDs can be adopted as a suitable delivery and therapeutic strategy for the treatment of glioblastoma, by both directly destabilizing the cell membrane and indirectly increasing the efficacy of chemotherapeutic drugs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21176301