Mucoadhesive Mesoporous Silica Particles as Versatile Carriers for Doxorubicin Delivery in Cancer Therapy

Due to their structural, morphological, and behavioral characteristics (e.g., large volume and adjustable pore size, wide functionalization possibilities, excellent biocompatibility, stability, and controlled biodegradation, the ability to protect cargoes against premature release and unwanted degra...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-10, Vol.24 (19), p.14687
Main Authors: Zaltariov, Mirela-Fernanda, Ciubotaru, Bianca-Iulia, Ghilan, Alina, Peptanariu, Dragos, Ignat, Maria, Iacob, Mihail, Vornicu, Nicoleta, Cazacu, Maria
Format: Article
Language:English
Subjects:
antimicrobial activity
Biodegradation
Cancer
Cancer therapies
Care and treatment
Cellulose
Clinical trials
Cytotoxicity
Deformation
doxorubicin carrier
Drug delivery systems
Drugs
Health aspects
mesoporous silica particles
mucoadhesion test
Nanoparticles
Particle size
Polyethylene glycol
Pore size
Silica
Spectrum analysis
Tomography
Toxicity
Vehicles
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Summary:Due to their structural, morphological, and behavioral characteristics (e.g., large volume and adjustable pore size, wide functionalization possibilities, excellent biocompatibility, stability, and controlled biodegradation, the ability to protect cargoes against premature release and unwanted degradation), mesoporous silica particles (MSPs) are emerging as a promising diagnostic and delivery platform with a key role in the development of next-generation theranostics, nanovaccines, and formulations. In this study, MSPs with customized characteristics in-lab prepared were fully characterized and used as carriers for doxorubicin (DOX). The drug loading capacity and the release profile were evaluated in media with different pH values, mimicking the body conditions. The release data were fitted to Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin kinetic models to evaluate the release constant and the mechanism. The in vitro behavior of functionalized silica particles showed an enhanced cytotoxicity on human breast cancer (MCF-7) cells. Bio- and mucoadhesion on different substrates (synthetic cellulose membrane and porcine tissue mucosa)) and antimicrobial activity were successfully assessed, proving the ability of the OH- or the organically modified MSPs to act as antimicrobial and mucoadhesive platforms for drug delivery systems with synergistic effects.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241914687