In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis

The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no...

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-14
Main Authors: De Marzi, Laura, Santucci, Sandro, Aimola, Pierpaolo, Borras, Miquel, Ramos, David, de Lapuente, Joaquin, Ragnelli, Anna Maria, Poma, Anna, Di Gioacchino, Mario
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Blood Chemical Analysis
Cerium - administration & dosage
Cerium - chemistry
Cerium - toxicity
Colleges & universities
Cytotoxicity
Diesel fuels
Drug dosages
Erythrocyte Indices
Female
Free radicals
Hematology
Immunology
Inflammation - blood
Inflammation - chemically induced
Inflammation - pathology
Kidney - drug effects
Kidney - pathology
Kidney - ultrastructure
Liver - drug effects
Liver - pathology
Liver - ultrastructure
Lung - drug effects
Lung - pathology
Lung - ultrastructure
Macrophages - drug effects
Macrophages - pathology
Macrophages - ultrastructure
Male
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Metal Nanoparticles - toxicity
Metal Nanoparticles - ultrastructure
Mice
Nanoparticles
Oxidative stress
Peyer's Patches - drug effects
Peyer's Patches - pathology
Rodents
Toxicity Tests - methods
Toxicology
VOCs
Volatile organic compounds
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Summary:The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations. TEM analysis showed the presence of NPs in alveolar macrophages. Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation).
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/361419