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First Acyclovir Determination Procedure via Electrochemically Activated Screen-Printed Carbon Electrode Coupled with Well-Conductive Base Electrolyte
In this work, a new voltammetric procedure for acyclovir (ACY) trace-level determination has been described. For this purpose, an electrochemically activated screen-printed carbon electrode (aSPCE) coupled with well-conductive electrolyte (CH COONH , CH COOH and NH Cl) was used for the first time. A...
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| Published in: | Sensors (Basel, Switzerland) Switzerland), 2024-02, Vol.24 (4), p.1125 |
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| container_issue | 4 |
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| container_title | Sensors (Basel, Switzerland) |
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| creator | Tyszczuk-Rotko, Katarzyna Staniec, Katarzyna Gorylewski, Damian Keller, Aleksy |
| description | In this work, a new voltammetric procedure for acyclovir (ACY) trace-level determination has been described. For this purpose, an electrochemically activated screen-printed carbon electrode (aSPCE) coupled with well-conductive electrolyte (CH
COONH
, CH
COOH and NH
Cl) was used for the first time. A commercially available SPCE sensor was electrochemically activated by conducting cyclic voltammetry (CV) scans in 0.1 mol L
NaOH solution and rinsed with deionized water before a series of measurements were taken. This treatment reduced the charge transfer resistance, increased the electrode active surface area and improved the kinetics of the electron transfer. The activation step and high conductivity of supporting electrolyte significantly improved the sensitivity of the procedure. The newly developed differential-pulse adsorptive stripping voltammetry (DPAdSV) procedure is characterized by having the lowest limit of detection among all voltammetric procedures currently described in the literature (0.12 nmol L
), a wide linear range of the calibration curve (0.5-50.0 and 50.0-1000.0 nmol L
) as well as extremely high sensitivity (90.24 nA nmol L
) and was successfully applied in the determination of acyclovir in commercially available pharmaceuticals. |
| doi_str_mv | 10.3390/s24041125 |
| format | article |
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COONH
, CH
COOH and NH
Cl) was used for the first time. A commercially available SPCE sensor was electrochemically activated by conducting cyclic voltammetry (CV) scans in 0.1 mol L
NaOH solution and rinsed with deionized water before a series of measurements were taken. This treatment reduced the charge transfer resistance, increased the electrode active surface area and improved the kinetics of the electron transfer. The activation step and high conductivity of supporting electrolyte significantly improved the sensitivity of the procedure. The newly developed differential-pulse adsorptive stripping voltammetry (DPAdSV) procedure is characterized by having the lowest limit of detection among all voltammetric procedures currently described in the literature (0.12 nmol L
), a wide linear range of the calibration curve (0.5-50.0 and 50.0-1000.0 nmol L
) as well as extremely high sensitivity (90.24 nA nmol L
) and was successfully applied in the determination of acyclovir in commercially available pharmaceuticals.</description><identifier>ISSN: 1424-8220</identifier><identifier>EISSN: 1424-8220</identifier><identifier>DOI: 10.3390/s24041125</identifier><identifier>PMID: 38400283</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acyclovir ; Antiviral drugs ; Carbon ; Chromatography ; Electrodes ; Electrolytes ; Electrons ; Graphene ; Graphite ; Health aspects ; Herpes viruses ; Infection ; Infections ; Nanoparticles ; Penciclovir ; pharmaceutical samples ; Pharmaceuticals ; Reagents ; screen-printed electrode ; sensitivity improvement ; Sensors ; Urine ; Voltammetry ; well-conductive electrolyte</subject><ispartof>Sensors (Basel, Switzerland), 2024-02, Vol.24 (4), p.1125</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c497t-ade68647f3dd87d66ea462e8d0c7bab721d5485fe914d1b6d7e203bc8a0cc6143</cites><orcidid>0000-0003-2347-421X ; 0009-0008-8802-9719 ; 0000-0001-5893-5309</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2931099432/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2931099432?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772,74873</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38400283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tyszczuk-Rotko, Katarzyna</creatorcontrib><creatorcontrib>Staniec, Katarzyna</creatorcontrib><creatorcontrib>Gorylewski, Damian</creatorcontrib><creatorcontrib>Keller, Aleksy</creatorcontrib><title>First Acyclovir Determination Procedure via Electrochemically Activated Screen-Printed Carbon Electrode Coupled with Well-Conductive Base Electrolyte</title><title>Sensors (Basel, Switzerland)</title><addtitle>Sensors (Basel)</addtitle><description>In this work, a new voltammetric procedure for acyclovir (ACY) trace-level determination has been described. For this purpose, an electrochemically activated screen-printed carbon electrode (aSPCE) coupled with well-conductive electrolyte (CH
COONH
, CH
COOH and NH
Cl) was used for the first time. A commercially available SPCE sensor was electrochemically activated by conducting cyclic voltammetry (CV) scans in 0.1 mol L
NaOH solution and rinsed with deionized water before a series of measurements were taken. This treatment reduced the charge transfer resistance, increased the electrode active surface area and improved the kinetics of the electron transfer. The activation step and high conductivity of supporting electrolyte significantly improved the sensitivity of the procedure. The newly developed differential-pulse adsorptive stripping voltammetry (DPAdSV) procedure is characterized by having the lowest limit of detection among all voltammetric procedures currently described in the literature (0.12 nmol L
), a wide linear range of the calibration curve (0.5-50.0 and 50.0-1000.0 nmol L
) as well as extremely high sensitivity (90.24 nA nmol L
) and was successfully applied in the determination of acyclovir in commercially available pharmaceuticals.</description><subject>Acyclovir</subject><subject>Antiviral drugs</subject><subject>Carbon</subject><subject>Chromatography</subject><subject>Electrodes</subject><subject>Electrolytes</subject><subject>Electrons</subject><subject>Graphene</subject><subject>Graphite</subject><subject>Health aspects</subject><subject>Herpes viruses</subject><subject>Infection</subject><subject>Infections</subject><subject>Nanoparticles</subject><subject>Penciclovir</subject><subject>pharmaceutical samples</subject><subject>Pharmaceuticals</subject><subject>Reagents</subject><subject>screen-printed electrode</subject><subject>sensitivity improvement</subject><subject>Sensors</subject><subject>Urine</subject><subject>Voltammetry</subject><subject>well-conductive electrolyte</subject><issn>1424-8220</issn><issn>1424-8220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks9uEzEQxlcIREvhwAuglbjAYYv_rdc-oRBaqFSJSoA4Wl57NnHkrFOvNygPwvviJWloEfLB9szv-yzPTFG8xOicUoneDYQhhjGpHxWnmBFWCULQ43vnk-LZMKwQIpRS8bQ4oYLli6Cnxa9LF4dUzszO-LB1sfwICeLa9Tq50Jc3MRiwY4Ry63R54cGkHFnC2hnt_S7rktvqBLb8aiJAX91E10_XuY5t1h8UFsp5GDc-J366tCx_gPfVPPR2nPRQftAD3LF-l-B58aTTfoAXh_2s-H558W3-ubr-8ulqPruuDJNNqrQFLjhrOmqtaCznoBknICwyTavbhmBbM1F3IDGzuOW2AYJoa4RGxnDM6Flxtfe1Qa_UJrq1jjsVtFN_AiEulI7JGQ_KcGmg06zjDWayM4Jb2WhOGeK17ITMXu_3XpuxXYM10Keo_QPTh5neLdUibBVGWU3rOju8OTjEcDvCkNTaDSaXSvcQxkERSQnLDZc8o6__QVdhjH2u1URhJCWj5C-10PkHru9CfthMpmrWCIYREw3O1Pl_qLzs1ObQQ-dy_IHg7V5gYhiGCN3xkxipaSDVcSAz--p-VY7k3QTS3-fE3FU</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Tyszczuk-Rotko, Katarzyna</creator><creator>Staniec, Katarzyna</creator><creator>Gorylewski, Damian</creator><creator>Keller, Aleksy</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2347-421X</orcidid><orcidid>https://orcid.org/0009-0008-8802-9719</orcidid><orcidid>https://orcid.org/0000-0001-5893-5309</orcidid></search><sort><creationdate>20240201</creationdate><title>First Acyclovir Determination Procedure via Electrochemically Activated Screen-Printed Carbon Electrode Coupled with Well-Conductive Base Electrolyte</title><author>Tyszczuk-Rotko, Katarzyna ; Staniec, Katarzyna ; Gorylewski, Damian ; Keller, Aleksy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-ade68647f3dd87d66ea462e8d0c7bab721d5485fe914d1b6d7e203bc8a0cc6143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acyclovir</topic><topic>Antiviral drugs</topic><topic>Carbon</topic><topic>Chromatography</topic><topic>Electrodes</topic><topic>Electrolytes</topic><topic>Electrons</topic><topic>Graphene</topic><topic>Graphite</topic><topic>Health aspects</topic><topic>Herpes viruses</topic><topic>Infection</topic><topic>Infections</topic><topic>Nanoparticles</topic><topic>Penciclovir</topic><topic>pharmaceutical samples</topic><topic>Pharmaceuticals</topic><topic>Reagents</topic><topic>screen-printed electrode</topic><topic>sensitivity improvement</topic><topic>Sensors</topic><topic>Urine</topic><topic>Voltammetry</topic><topic>well-conductive electrolyte</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tyszczuk-Rotko, Katarzyna</creatorcontrib><creatorcontrib>Staniec, Katarzyna</creatorcontrib><creatorcontrib>Gorylewski, Damian</creatorcontrib><creatorcontrib>Keller, Aleksy</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Sensors (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tyszczuk-Rotko, Katarzyna</au><au>Staniec, Katarzyna</au><au>Gorylewski, Damian</au><au>Keller, Aleksy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First Acyclovir Determination Procedure via Electrochemically Activated Screen-Printed Carbon Electrode Coupled with Well-Conductive Base Electrolyte</atitle><jtitle>Sensors (Basel, Switzerland)</jtitle><addtitle>Sensors (Basel)</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>24</volume><issue>4</issue><spage>1125</spage><pages>1125-</pages><issn>1424-8220</issn><eissn>1424-8220</eissn><abstract>In this work, a new voltammetric procedure for acyclovir (ACY) trace-level determination has been described. For this purpose, an electrochemically activated screen-printed carbon electrode (aSPCE) coupled with well-conductive electrolyte (CH
COONH
, CH
COOH and NH
Cl) was used for the first time. A commercially available SPCE sensor was electrochemically activated by conducting cyclic voltammetry (CV) scans in 0.1 mol L
NaOH solution and rinsed with deionized water before a series of measurements were taken. This treatment reduced the charge transfer resistance, increased the electrode active surface area and improved the kinetics of the electron transfer. The activation step and high conductivity of supporting electrolyte significantly improved the sensitivity of the procedure. The newly developed differential-pulse adsorptive stripping voltammetry (DPAdSV) procedure is characterized by having the lowest limit of detection among all voltammetric procedures currently described in the literature (0.12 nmol L
), a wide linear range of the calibration curve (0.5-50.0 and 50.0-1000.0 nmol L
) as well as extremely high sensitivity (90.24 nA nmol L
) and was successfully applied in the determination of acyclovir in commercially available pharmaceuticals.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38400283</pmid><doi>10.3390/s24041125</doi><orcidid>https://orcid.org/0000-0003-2347-421X</orcidid><orcidid>https://orcid.org/0009-0008-8802-9719</orcidid><orcidid>https://orcid.org/0000-0001-5893-5309</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Sensors (Basel, Switzerland), 2024-02, Vol.24 (4), p.1125 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Acyclovir Antiviral drugs Carbon Chromatography Electrodes Electrolytes Electrons Graphene Graphite Health aspects Herpes viruses Infection Infections Nanoparticles Penciclovir pharmaceutical samples Pharmaceuticals Reagents screen-printed electrode sensitivity improvement Sensors Urine Voltammetry well-conductive electrolyte |
| title | First Acyclovir Determination Procedure via Electrochemically Activated Screen-Printed Carbon Electrode Coupled with Well-Conductive Base Electrolyte |
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