Effect of Cerebral Small Vessel Disease Burden on Infarct Growth Rate and Stroke Outcomes in Large Vessel Occlusion Stroke Receiving Endovascular Treatment

This study aimed to investigate the association between cerebral small vessel disease (CSVD) burden and infarct growth rate (IGR) in patients with large vessel occlusion (LVO) stroke who underwent endovascular treatment (EVT). A retrospective analysis was conducted on a cohort of 495 patients with a...

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Published in:Biomedicines 2023-11, Vol.11 (11), p.3102
Main Authors: Sohn, Jong-Hee, Kim, Yejin, Kim, Chulho, Sung, Joo Hye, Han, Sang-Won, Kim, Yerim, Park, Soo-Hyun, Lee, Minwoo, Yu, Kyung-Ho, Lee, Jae Jun, Lee, Sang-Hwa
Format: Article
Language:English
Subjects:
Biomarkers
Cardiovascular system
Cerebral blood flow
cerebral small vessel disease
Diagnostic imaging
Drunk driving
endovascular treatment
Growth rate
infarct growth
Ischemia
large vessel occlusion
Magnetic resonance imaging
Medical imaging
Neuroimaging
Patients
prognosis
Regression analysis
Stroke
stroke progression
Vascular diseases
Volumetric analysis
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Summary:This study aimed to investigate the association between cerebral small vessel disease (CSVD) burden and infarct growth rate (IGR) in patients with large vessel occlusion (LVO) stroke who underwent endovascular treatment (EVT). A retrospective analysis was conducted on a cohort of 495 patients with anterior circulation stroke who received EVT. CSVD burden was assessed using a CSVD score based on neuroimaging features. IGR was calculated from diffusion-weighted imaging (DWI) lesion volumes divided by the time from stroke onset to imaging. Clinical outcomes included stroke progression and functional outcomes at 3 months. Multivariate analyses were performed to assess the relationship between CSVD burden, IGR, and clinical outcomes. The fast IGR group had a higher proportion of high CSVD scores than the slow IGR group (24.4% vs. 0.8%, p < 0.001). High CSVD burden was significantly associated with a faster IGR (odds ratio [95% confidence interval], 26.26 [6.26–110.14], p < 0.001) after adjusting for confounding factors. High CSVD burden also independently predicted stroke progression and poor functional outcomes. This study highlights a significant relationship between CSVD burden and IGR in LVO stroke patients undergoing EVT. High CSVD burden was associated with faster infarct growth and worse clinical outcomes.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11113102