Interspecies Diversity of Osmotic Gradient Deformability of Red Blood Cells in Human and Seven Vertebrate Animal Species

Plasma and blood osmolality values show interspecies differences and are strictly regulated. The effect of these factors also has an influence on microrheological parameters, such as red blood cell (RBC) deformability and aggregation. However, little is known about the interspecies differences in RB...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-04, Vol.11 (8), p.1351
Main Authors: Varga, Adam, Matrai, Adam Attila, Barath, Barbara, Deak, Adam, Horvath, Laszlo, Nemeth, Norbert
Format: Article
Language:English
Subjects:
Animals
Blood
Deformability
Dogs
Elongation
Erythrocyte Count
Erythrocyte Deformability
Erythrocyte Indices
Erythrocytes
Experiments
Hematology
Hemoglobin
hemorheology
Humans
interspecies diversity
Ischemia
Laboratory animals
Metabolism
Mice
Morphology
osmoscan
osmotic gradient deformability
Osmotic pressure
Rabbits
Rats
red blood cell deformability
Sepsis
Shear stress
Sheep
Species
Swine
Veins & arteries
Vertebrates
Viscosity
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Summary:Plasma and blood osmolality values show interspecies differences and are strictly regulated. The effect of these factors also has an influence on microrheological parameters, such as red blood cell (RBC) deformability and aggregation. However, little is known about the interspecies differences in RBC deformability at various blood osmolality levels (osmotic gradient RBC deformability). Our aim was to conduct a descriptive-comparative study on RBC osmotic gradient deformability in several vertebrate species and human blood. Blood samples were taken from healthy volunteers, dogs, cats, pigs, sheep, rabbits, rats, and mice, to measure hematological parameters, as well as conventional and osmotic gradient RBC deformability. Analyzing the elongation index (EI)-osmolality curves, we found the highest maximal EI values (EI max) in human, dog, and rabbit samples. The lowest EI max values were seen in sheep and cat samples, in addition to a characteristic leftward shift of the elongation index-osmolality curves. We found significant differences in the hyperosmolar region. A correlation of mean corpuscular volume and mean corpuscular hemoglobin concentration with osmoscan parameters was found. Osmotic gradient deformability provides further information for better exploration of microrheological diversity between species and may help to better understand the alterations caused by osmolality changes in various disorders.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11081351