Tourniquet use benefits to reduce intraoperative blood loss in patients receiving total knee arthroplasty for osteoarthritis: An updated meta-analysis with trial sequential analysis

• Published in: Journal of orthopaedic surgery (Hong Kong) 2023-05, Vol.31 (2), p.10225536231191607-10225536231191607
• Main Authors: Xu, Xiangjun, Wang, Chao, Song, Qunshan, Mou, Zhifang, Dong, Yuefu
• Format: Article
• Language: English
• Subjects: Arthritis; Arthroplasty, Replacement, Knee - adverse effects; Arthroplasty, Replacement, Knee - methods; Blood Loss, Surgical - prevention & control; Humans; Joint replacement surgery; Knee; Meta-analysis; Osteoarthritis; Osteoarthritis, Knee - etiology; Osteoarthritis, Knee - surgery; Pain - etiology; Postoperative Hemorrhage - etiology; Randomized Controlled Trials as Topic; Tourniquets - adverse effects
• ISSN: 1022-5536; 2309-4990
• DOI: 10.1177/10225536231191607

Purpose The efficacy and safety of tourniquets use during total knee arthroplasty (TKA) in patients with osteoarthritis remain debated. This updated systematic review and meta-analysis aimed to further evaluate the role of tourniquets use in patients undergoing TKA for knee osteoarthritis by introducing trial sequential analysis. Methods PubMed, Embase, and the Cochrane Library were searched. We used the Cochrane risk of bias tool for quality assessment. Statistical heterogeneity across studies was evaluated using Cochran’s Q and I 2 statistic. Meta-analysis was performed using Stata/SE 14.0, and trail sequential analysis was performed using TSA software version 0.9.5.10 Beta. In addition, qualitative summary was also used to describe results. Results 15 randomized controlled trials (RCTs) involving 1202 patients were included in the meta-analysis. The pooled results showed that tourniquet use during TKA significantly reduced intraoperative blood loss (mean difference (MD)= −123.84, 95% confidence interval (CI): −163.37 to −84.32, p < .001)and shortened operation time (MD = −4.71, 95% CI: −7.6 to −1.82, p = .001), but there were no significant differences in postoperative blood loss, calculated blood loss, total blood loss, transfusion rate (p = .939), and deep venous thrombosis (DVT) rate between the tourniquet and no-tourniquet groups. TSA confirmed that the result of operation time was false positive, but the results of other outcomes were conclusive. The results of qualitative summary showed conflicting findings in terms of pain, range of motion (RoM) and swelling ratio between the two groups. Conclusions Tourniquet use in patients receiving TKA for osteoarthritis benefits to reduce intraoperative blood loss but has no effect on postoperative blood loss, calculated blood loss, total blood loss, operation time, transfusion rate, and DVT rate. In addition, it remains unclear the difference between the tourniquet and non-tourniquet groups in terms of pain, RoM and swelling ratio.