Acquired long QT syndrome and Torsades de Poin

Acetylcholinesterase inhibitors are group of drugs commonly used in Alzheimer disease and have beneficial effects on treatment. Although they have many known side effects, cardiovascular side effects are rarely seen. We present a 84 year old female who was admitted to emergency service due to repeti...

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Bibliographic Details
Published in:The Egyptian heart journal 2016-09, Vol.68 (3), p.197-199
Main Authors: Ahmet Seyfeddin Gurbuz, Semi Ozturk, Emrah Acar, Süleyman Çagan Efe, Taylan Akgun, Alev Kilicgedik, Ahmet Guler, Cevat Kirma
Format: Article
Language:English
Subjects:
AChIs
Donepezil
QT prolongation
Syncope
Torsades de Pointes
Online Access:Get full text
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Summary:Acetylcholinesterase inhibitors are group of drugs commonly used in Alzheimer disease and have beneficial effects on treatment. Although they have many known side effects, cardiovascular side effects are rarely seen. We present a 84 year old female who was admitted to emergency service due to repetitive syncope episodes while taking donepezil. Her electrocardiogram showed QT prolongation and on follow-up a Torsades de Pointes episode occurred. Patient was discharged with normal corrected QT time after removal of donepezil.
ISSN:1110-2608
DOI:10.1016/j.ehj.2015.07.004