Chemical composition and antioxidant content of Thymus vulgaris honey and Origanum vulgare essential oil; their effect on carbon tetrachloride-induced toxicity

The study investigated the chemical composition, antioxidant content, and antioxidant activity of honey (TVH) and essential oil (OVEO) and their mixture effect on carbon tetrachloride (CCl )-induced toxicity. The study conducted physicochemical characterization and chemical analysis of TVH and OVEO...

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Bibliographic Details
Published in:Veterinary World 2021-01, Vol.14 (1), p.292-301
Main Authors: Imtara, Hamada, Al-Waili, Noori, Aboulghazi, Abderrazak, Abdellaoui, Abdelfattah, Al-Waili, Thia, Lyoussi, Badiaa
Format: Article
Language:English
Subjects:
Antioxidants
Carbon tetrachloride
Carvacrol
Chemical composition
Epicatechin
Essential oils
Flavonoids
Gas chromatography
High-performance liquid chromatography
Honey
Kidneys
Liver
Mass spectroscopy
Oils & fats
Origanum vulgare
origanum vulgare essential oil
Thymol
thymus honey
Thymus vulgaris
Toxicity
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Summary:The study investigated the chemical composition, antioxidant content, and antioxidant activity of honey (TVH) and essential oil (OVEO) and their mixture effect on carbon tetrachloride (CCl )-induced toxicity. The study conducted physicochemical characterization and chemical analysis of TVH and OVEO with the use of gas chromatography-mass spectrometry and high-performance liquid chromatograph (HPLC). The antioxidant activity of TVH and OVEO was done with the use of 1,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. The study used nine groups of rats to investigate the effect of TVH, OVEO, and a mixture of TVH and OVEO (HEM) on CCl -induced toxicity. Intraperitoneal injection of CCl (1 mL/100 g) was used to induce toxicity. The doses of TVH and OVEO were 1 mg/kg.b.wt, and 50 mg/kg.b.wt, respectively. HEM contains TVH (1 mg/kg.b.wt) and OVEO (50 mg/kg.b.wt). TVH has a high content of phenols, flavonoids, and flavanols. HPLC analysis showed that TVH contains, for the 1 time, epicatechin gallate, and at a high concentration. OVEO includes a high percentage of carvacrol and thymol. With the use of DPPH, OVEO was more potent than TVH. CCl caused significant liver and kidney damage and lipid disorders, which were alleviated by HVT, OVEO, and HEM. HVT was more potent than OVEO (p
ISSN:0972-8988
2231-0916
DOI:10.14202/vetworld.2021.292-301