Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition

• Published in: Future science OA 2020-10, Vol.6 (10), p.FSO589-FSO589
• Main Authors: Giúdice, Antonela Del, Pagura, Lucas, Capitani, María Celeste, Mainetti, Leandro Ernesto, Scharovsky, O Graciela, Di Masso, Ricardo José, Rico, María José, Rozados, Viviana Rosa
• Format: Article
• Language: English
• Subjects: cancer immunoediting; mammary adenocarcinoma; mathematical model
• ISSN: 2056-5623; 2056-5623
• DOI: 10.2144/fsoa-2019-0108

To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response. Breast cancer is a complex, multifactor disease that affects about 10% of women in industrialized countries. The immune system has the ability to monitor the appearance of tumors, but the tumors have the ability to escape such rejection. For this reason, in order to design different therapeutic strategies, it is important to know the different mechanisms that take place when a tumor grows or when it is rejected. Here we sought to elucidate some of these mechanisms.