Predictors of impaired SARS-CoV-2 immunity in healthcare workers after vaccination with BNT162b2

Healthcare workers are at substantially increased risk for infection with SARS-CoV-2. Successful vaccination constitutes a crucial prerequisite to protect this group during the pandemic. Since post vaccination antibody monitoring is not standard of care in all healthcare institutions, data on risk f...

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Bibliographic Details
Published in:Scientific reports 2022-04, Vol.12 (1), p.6243-6243, Article 6243
Main Authors: Bertram, Sebastian, Blazquez-Navarro, Arturo, Seidel, Maximilian, Hölzer, Bodo, Seibert, Felix S., Doevelaar, Adrian, Rohn, Benjamin, Zgoura, Panagiota, Witte-Lack, Alexandra, Skrzypczyk, Sarah, Scholten, David, Kisters, Klaus, Babel, Nina, Westhoff, Timm H.
Format: Article
Language:English
Subjects:
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Antibodies
Antibodies, Viral
BNT162 Vaccine
CD4 antigen
CD8 antigen
Cell-mediated immunity
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
Employees
Health care
Health Personnel
Humanities and Social Sciences
Humans
Immune response
Immune response (humoral)
Immunity, Humoral
Immunoglobulin G
Immunosuppression
Lymphocytes T
Medical personnel
multidisciplinary
Pandemics
Risk factors
SARS-CoV-2
Science
Science (multidisciplinary)
Seroconversion
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccines
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Summary:Healthcare workers are at substantially increased risk for infection with SARS-CoV-2. Successful vaccination constitutes a crucial prerequisite to protect this group during the pandemic. Since post vaccination antibody monitoring is not standard of care in all healthcare institutions, data on risk factors of impaired vaccine induced immune response are urgently required. Moreover, there are no data on cellular immune responses in humoral low responders so far. Anti-SARS-CoV-2 spike IgG was assessed after vaccination with BNT162b2 in 1386 employees of three hospitals of a German healthcare provider. Concentrations were compared to those of 45 convalescent employees. Vaccine-induced cellular immunity was measured in employees with reduced humoral response by assessment of frequencies of SARS-CoV-2-reactive CD4 + and CD8 +  T cell. Anti-SARS-CoV-2 spike IgG were detected in 99.9% of 1386 healthcare workers after completed vaccination. The median antibody concentration was significantly higher after vaccination than after infection with SARS-CoV-2 (p = 0.0001). 10 subjects (0.7%) generated an IgG concentration 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10307-8