Abnormal regional homogeneity and its relationship with symptom severity in cervical dystonia: a rest state fMRI study

Although several brain networks play important roles in cervical dystonia (CD) patients, regional homogeneity (ReHo) changes in CD patients have not been clarified. We investigated to explore ReHo in CD patients at rest and analyzed its correlations with symptom severity as measured by Tsui scale. A...

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Bibliographic Details
Published in:BMC neurology 2021-02, Vol.21 (1), p.55-55, Article 55
Main Authors: Wei, Shubao, Lu, Chunhui, Chen, Xiuqiong, Yang, Lu, Wei, Jing, Jiang, Wenyan, Liu, Yang, Li, Hui Hui, Qin, Yuhong, Lei, Yiwu, Qin, Chao, Hu, Caiyou, Luo, Shuguang
Format: Article
Language:English
Subjects:
Adult
Age
Brain - diagnostic imaging
Brain - pathology
Brain mapping
Brain Mapping - methods
Cerebellum
Cervical dystonia
Contraindications
Default mode network
Diagnosis
Dystonia
Female
Functional magnetic resonance imaging
Humans
Image Interpretation, Computer-Assisted
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Mental disorders
Middle Aged
Neck pain
Pathophysiology
Patients
Precentral gyrus
Prefrontal cortex
Regional homogeneity
Resting-state functional magnetic resonance
Time series
Torticollis - diagnostic imaging
Torticollis - pathology
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Summary:Although several brain networks play important roles in cervical dystonia (CD) patients, regional homogeneity (ReHo) changes in CD patients have not been clarified. We investigated to explore ReHo in CD patients at rest and analyzed its correlations with symptom severity as measured by Tsui scale. A total of 19 CD patients and 21 gender-, age-, and education-matched healthy controls underwent fMRI scans at rest state. Data were analyzed by ReHo method. Patients showed increased ReHo in the right cerebellum crus I and decreased ReHo in the right superior medial prefrontal cortex (MPFC). Moreover, the right precentral gyrus, right insula, and bilateral middle cingulate gyrus also showed increased ReHo values. A significantly positive correlation was observed between ReHo value in the right cerebellum crus I and symptom severity (p 
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-021-02079-x