Wound-healing effect of honey gel and film

Background: Honey has been formulated into gel and film dosage forms for burn wound as previously reported. Aims: In this study, we evaluated the ability of honey gel and film to promote the healing of burns and incision wounds on the skin of Sprague-Dawley female white rats. Materials and Methods:...

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Bibliographic Details
Published in:Journal of pharmacy & bioallied science 2019-04, Vol.11 (2), p.176-180
Main Authors: Febriyenti, Febriyenti, Lucida, Henny, Almahdy, Almahdy, Alfikriyah, Istianah, Hanif, Muhammad
Format: Article
Language:English
Subjects:
Animal bites
B cells
Bacteria
Burn wound
Burns
Burns and scalds
Collagen
Data analysis
Enzymes
Fibroblasts
Honey
honey film
honey gel
Hydrogen peroxide
incision wound
Original
Polyvinyl alcohol
Skin
Tensile strength
Variance analysis
Wound healing
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Summary:Background: Honey has been formulated into gel and film dosage forms for burn wound as previously reported. Aims: In this study, we evaluated the ability of honey gel and film to promote the healing of burns and incision wounds on the skin of Sprague-Dawley female white rats. Materials and Methods: Twenty-four female rats were divided into four groups, which were treatment groups (for honey gel or film), negative control, and positive control (treated with marketed product "B"), respectively. Burn and incision wound were created by the method previously reported with slight modification. Parameters such as the percentage of wound closure and the tensile strength of the incision wound were determined. Results: The experimental results showed that honey film has a greater effectiveness to accelerate the healing for burns and incision wound in comparison to the negative control. Conclusions: Two-way analysis of variance indicates the type of treatment group, and time has a significant effect on the burn wound (P < 0.05). Honey film shows the significant difference (P < 0.05) with other group on the incision wound.
ISSN:0975-7406
0976-4879
0975-7406
DOI:10.4103/jpbs.JPBS_184_18