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Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs
Background Serum folate is considered a biomarker of chronic enteropathy (CE) in dogs, but few studies have examined associations with markers of CE. Hypothesis/Objectives To evaluate serum folate concentrations in dogs with and without CE and associations with sample hemolysis and selected markers...
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Published in: | Journal of veterinary internal medicine 2023-03, Vol.37 (2), p.455-464 |
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creator | Ullal, Tarini V. Marks, Stanley L. Huebner, Sara N. Taylor, Sandra L. Shelley, Courtney D. |
description | Background
Serum folate is considered a biomarker of chronic enteropathy (CE) in dogs, but few studies have examined associations with markers of CE.
Hypothesis/Objectives
To evaluate serum folate concentrations in dogs with and without CE and associations with sample hemolysis and selected markers of CE. We hypothesized that hypofolatemia would be more common in dogs with CE and associated with hypocobalaminemia, higher CIBDAI, and hypoalbuminemia.
Animals
Six hundred seventy‐three dogs with available serum folate measurements performed at an academic veterinary hospital between January 2016 and December 2019.
Methods
Medical records were retrospectively reviewed to categorize cases as CE or non‐CE and record clinical details and laboratory markers. Relationships between serum folate, cobalamin, and CE variables were assessed using chi‐square, Kruskal‐Wallis, or Spearman's correlation tests.
Results
Of the 673 dogs, 99 CE were compared to 95 non‐CE. In the overall cohort, serum folate concentration did not correlate with sample hemolysis (P = .75). In the CE subset, serum folate and cobalamin concentrations were positively associated (rho = 0.34, FDR = 0.02). However, serum folate concentrations (median [25th, 75th percentiles]) were higher (CE: 12.1 (8.9, 16.1), non‐CE: 10.4 (7.2, 15.5); P = .04) and cobalamin concentrations were lower (CE: 343 (240, 597), non‐CE: 550 (329, 749); P = .001) in the CE vs non‐CE group. Serum folate was not associated with markers of CE, but serum cobalamin was associated with albumin (P = .04) and cholesterol (P = .03).
Conclusions and Clinical Importance
Hypofolatemia is an inferior biomarker of CE compared to hypocobalaminemia. |
doi_str_mv | 10.1111/jvim.16681 |
format | article |
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Serum folate is considered a biomarker of chronic enteropathy (CE) in dogs, but few studies have examined associations with markers of CE.
Hypothesis/Objectives
To evaluate serum folate concentrations in dogs with and without CE and associations with sample hemolysis and selected markers of CE. We hypothesized that hypofolatemia would be more common in dogs with CE and associated with hypocobalaminemia, higher CIBDAI, and hypoalbuminemia.
Animals
Six hundred seventy‐three dogs with available serum folate measurements performed at an academic veterinary hospital between January 2016 and December 2019.
Methods
Medical records were retrospectively reviewed to categorize cases as CE or non‐CE and record clinical details and laboratory markers. Relationships between serum folate, cobalamin, and CE variables were assessed using chi‐square, Kruskal‐Wallis, or Spearman's correlation tests.
Results
Of the 673 dogs, 99 CE were compared to 95 non‐CE. In the overall cohort, serum folate concentration did not correlate with sample hemolysis (P = .75). In the CE subset, serum folate and cobalamin concentrations were positively associated (rho = 0.34, FDR = 0.02). However, serum folate concentrations (median [25th, 75th percentiles]) were higher (CE: 12.1 (8.9, 16.1), non‐CE: 10.4 (7.2, 15.5); P = .04) and cobalamin concentrations were lower (CE: 343 (240, 597), non‐CE: 550 (329, 749); P = .001) in the CE vs non‐CE group. Serum folate was not associated with markers of CE, but serum cobalamin was associated with albumin (P = .04) and cholesterol (P = .03).
Conclusions and Clinical Importance
Hypofolatemia is an inferior biomarker of CE compared to hypocobalaminemia.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.16681</identifier><identifier>PMID: 36919188</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Antibiotics ; Biomarkers ; Cholesterol ; CIBDAI ; Diarrhea ; Diet ; DNA methylation ; Dog Diseases - diagnosis ; Dogs ; Folic Acid ; food‐responsive enteropathy ; Gastrointestinal diseases ; Hemoglobin ; Hemolysis ; immunosuppressant‐responsive enteropathy ; Inflammatory bowel disease ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - veterinary ; Laboratories ; Medical records ; Metabolism ; Proteins ; Retrospective Studies ; SMALL ANIMAL ; Teaching hospitals ; Vitamin B ; Vitamin B 12 ; Vitamin B 12 Deficiency - veterinary</subject><ispartof>Journal of veterinary internal medicine, 2023-03, Vol.37 (2), p.455-464</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.</rights><rights>2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5151-30ade586fc80d86f70d352b2397c6cbd050ed38c0d7e843ed44b57a5364cf3123</citedby><cites>FETCH-LOGICAL-c5151-30ade586fc80d86f70d352b2397c6cbd050ed38c0d7e843ed44b57a5364cf3123</cites><orcidid>0000-0001-7811-812X ; 0000-0001-7991-702X ; 0000-0002-8728-3706</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2792291029/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2792291029?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,37013,44590,46052,46476,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36919188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ullal, Tarini V.</creatorcontrib><creatorcontrib>Marks, Stanley L.</creatorcontrib><creatorcontrib>Huebner, Sara N.</creatorcontrib><creatorcontrib>Taylor, Sandra L.</creatorcontrib><creatorcontrib>Shelley, Courtney D.</creatorcontrib><title>Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Serum folate is considered a biomarker of chronic enteropathy (CE) in dogs, but few studies have examined associations with markers of CE.
Hypothesis/Objectives
To evaluate serum folate concentrations in dogs with and without CE and associations with sample hemolysis and selected markers of CE. We hypothesized that hypofolatemia would be more common in dogs with CE and associated with hypocobalaminemia, higher CIBDAI, and hypoalbuminemia.
Animals
Six hundred seventy‐three dogs with available serum folate measurements performed at an academic veterinary hospital between January 2016 and December 2019.
Methods
Medical records were retrospectively reviewed to categorize cases as CE or non‐CE and record clinical details and laboratory markers. Relationships between serum folate, cobalamin, and CE variables were assessed using chi‐square, Kruskal‐Wallis, or Spearman's correlation tests.
Results
Of the 673 dogs, 99 CE were compared to 95 non‐CE. In the overall cohort, serum folate concentration did not correlate with sample hemolysis (P = .75). In the CE subset, serum folate and cobalamin concentrations were positively associated (rho = 0.34, FDR = 0.02). However, serum folate concentrations (median [25th, 75th percentiles]) were higher (CE: 12.1 (8.9, 16.1), non‐CE: 10.4 (7.2, 15.5); P = .04) and cobalamin concentrations were lower (CE: 343 (240, 597), non‐CE: 550 (329, 749); P = .001) in the CE vs non‐CE group. Serum folate was not associated with markers of CE, but serum cobalamin was associated with albumin (P = .04) and cholesterol (P = .03).
Conclusions and Clinical Importance
Hypofolatemia is an inferior biomarker of CE compared to hypocobalaminemia.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Biomarkers</subject><subject>Cholesterol</subject><subject>CIBDAI</subject><subject>Diarrhea</subject><subject>Diet</subject><subject>DNA methylation</subject><subject>Dog Diseases - diagnosis</subject><subject>Dogs</subject><subject>Folic Acid</subject><subject>food‐responsive enteropathy</subject><subject>Gastrointestinal diseases</subject><subject>Hemoglobin</subject><subject>Hemolysis</subject><subject>immunosuppressant‐responsive enteropathy</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - veterinary</subject><subject>Laboratories</subject><subject>Medical records</subject><subject>Metabolism</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>SMALL ANIMAL</subject><subject>Teaching hospitals</subject><subject>Vitamin B</subject><subject>Vitamin B 12</subject><subject>Vitamin B 12 Deficiency - veterinary</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1rVDEUhoModlrd-AMk4KYUpubj5mslpfgxUnGjbkNukjuTMZOMyZ2W-fdm5tZiXZjNgZOHh5fDC8ArjC5xe2_Xt2FziTmX-AmYYUXVHHPBn4IZkgrPOe_QCTitdY0QYYyJ5-CEcoUVlnIG0lWt2QYzhpxgHuCQoxk9tDlZn8Zy3Fd4F8YVtDGkYE2ENSzbziQHo-lzY3LZw40pP32pB4ddldxI2AS-5K0ZV3sYEnR5WV-AZ4OJ1b-8n2fg-4f3364_zW--flxcX93MLcMMzykyzjPJByuRa0MgRxnpCVXCcts7xJB3VFrkhJcd9a7reiYMo7yzA8WEnoHF5HXZrPW2hBZvr7MJ-rjIZalNGYONXjchV81AvPKdsEQNXBDJmOkppqYbmuvd5Nru-o13013iI-njnxRWeplvNUaIYyx5M5zfG0r-tfN11JtQrY_RJJ93VRMhBWmpFWrom3_Qdd6V1G7VKEWIwoioRl1MlC251uKHhzQY6UMn9KET-tiJBr_-O_8D-qcEDcATcBei3_9HpT__WHyZpL8BBEXD2A</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Ullal, Tarini V.</creator><creator>Marks, Stanley L.</creator><creator>Huebner, Sara N.</creator><creator>Taylor, Sandra L.</creator><creator>Shelley, Courtney D.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7811-812X</orcidid><orcidid>https://orcid.org/0000-0001-7991-702X</orcidid><orcidid>https://orcid.org/0000-0002-8728-3706</orcidid></search><sort><creationdate>202303</creationdate><title>Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs</title><author>Ullal, Tarini V. ; Marks, Stanley L. ; Huebner, Sara N. ; Taylor, Sandra L. ; Shelley, Courtney D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5151-30ade586fc80d86f70d352b2397c6cbd050ed38c0d7e843ed44b57a5364cf3123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Antibiotics</topic><topic>Biomarkers</topic><topic>Cholesterol</topic><topic>CIBDAI</topic><topic>Diarrhea</topic><topic>Diet</topic><topic>DNA methylation</topic><topic>Dog Diseases - diagnosis</topic><topic>Dogs</topic><topic>Folic Acid</topic><topic>food‐responsive enteropathy</topic><topic>Gastrointestinal diseases</topic><topic>Hemoglobin</topic><topic>Hemolysis</topic><topic>immunosuppressant‐responsive enteropathy</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - veterinary</topic><topic>Laboratories</topic><topic>Medical records</topic><topic>Metabolism</topic><topic>Proteins</topic><topic>Retrospective Studies</topic><topic>SMALL ANIMAL</topic><topic>Teaching hospitals</topic><topic>Vitamin B</topic><topic>Vitamin B 12</topic><topic>Vitamin B 12 Deficiency - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ullal, Tarini V.</creatorcontrib><creatorcontrib>Marks, Stanley L.</creatorcontrib><creatorcontrib>Huebner, Sara N.</creatorcontrib><creatorcontrib>Taylor, Sandra L.</creatorcontrib><creatorcontrib>Shelley, Courtney D.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ullal, Tarini V.</au><au>Marks, Stanley L.</au><au>Huebner, Sara N.</au><au>Taylor, Sandra L.</au><au>Shelley, Courtney D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2023-03</date><risdate>2023</risdate><volume>37</volume><issue>2</issue><spage>455</spage><epage>464</epage><pages>455-464</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Serum folate is considered a biomarker of chronic enteropathy (CE) in dogs, but few studies have examined associations with markers of CE.
Hypothesis/Objectives
To evaluate serum folate concentrations in dogs with and without CE and associations with sample hemolysis and selected markers of CE. We hypothesized that hypofolatemia would be more common in dogs with CE and associated with hypocobalaminemia, higher CIBDAI, and hypoalbuminemia.
Animals
Six hundred seventy‐three dogs with available serum folate measurements performed at an academic veterinary hospital between January 2016 and December 2019.
Methods
Medical records were retrospectively reviewed to categorize cases as CE or non‐CE and record clinical details and laboratory markers. Relationships between serum folate, cobalamin, and CE variables were assessed using chi‐square, Kruskal‐Wallis, or Spearman's correlation tests.
Results
Of the 673 dogs, 99 CE were compared to 95 non‐CE. In the overall cohort, serum folate concentration did not correlate with sample hemolysis (P = .75). In the CE subset, serum folate and cobalamin concentrations were positively associated (rho = 0.34, FDR = 0.02). However, serum folate concentrations (median [25th, 75th percentiles]) were higher (CE: 12.1 (8.9, 16.1), non‐CE: 10.4 (7.2, 15.5); P = .04) and cobalamin concentrations were lower (CE: 343 (240, 597), non‐CE: 550 (329, 749); P = .001) in the CE vs non‐CE group. Serum folate was not associated with markers of CE, but serum cobalamin was associated with albumin (P = .04) and cholesterol (P = .03).
Conclusions and Clinical Importance
Hypofolatemia is an inferior biomarker of CE compared to hypocobalaminemia.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>36919188</pmid><doi>10.1111/jvim.16681</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7811-812X</orcidid><orcidid>https://orcid.org/0000-0001-7991-702X</orcidid><orcidid>https://orcid.org/0000-0002-8728-3706</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Antibiotics Biomarkers Cholesterol CIBDAI Diarrhea Diet DNA methylation Dog Diseases - diagnosis Dogs Folic Acid food‐responsive enteropathy Gastrointestinal diseases Hemoglobin Hemolysis immunosuppressant‐responsive enteropathy Inflammatory bowel disease Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - veterinary Laboratories Medical records Metabolism Proteins Retrospective Studies SMALL ANIMAL Teaching hospitals Vitamin B Vitamin B 12 Vitamin B 12 Deficiency - veterinary |
title | Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs |
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