Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review

The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (20), p.6953
Main Authors: Munawar, Saba, Zahoor, Ameer Fawad, Ali, Shafaqat, Javed, Sadia, Irfan, Muhammad, Irfan, Ali, Kotwica-Mojzych, Katarzyna, Mojzych, Mariusz
Format: Article
Language:English
Subjects:
Acids
Alcohol
alkaloids
amino acids
Biological Products
Esters
Functional groups
lignans
Mitsunobu reaction
Natural products
Organic chemistry
Organic compounds
Oxidants
Oxidation
Oxidizing agents
Phenols
Phosphines
polyketides
Reducing Agents
Review
Stereoselectivity
Substitution reactions
Synthesis
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Summary:The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (phosphines). It is a renowned stereoselective reaction which inverts the stereochemical configuration of end products. One of the most important applications of the Mitsunobu reaction is its role in the synthesis of natural products. This review article will focus on the contribution of the Mitsunobu reaction towards the total synthesis of natural products, highlighting their biological potential during recent years.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27206953