Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies

Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb-) has been reported. However, little is known about the clinicopathological characteristics and prognosis of this subtype. A tot...

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Bibliographic Details
Published in:Renal failure 2024-12, Vol.46 (1), p.2297015
Main Authors: Li, Xue, Shen, Yang, Li, Yanchun, Ma, Lijie, Sun, Qianmei
Format: Article
Language:English
Subjects:
Albumin
Albumins
Antibodies
Autoantibodies
Biopsy
Cholesterol
Clinical Study
Glomerulonephritis, Membranous - pathology
Humans
Kidneys
Low density lipoprotein
Membranous nephropathy
Nephropathy
Phospholipase A2
Phospholipase A2 receptor
Prognosis
proteinuria
Receptors, Phospholipase A2
Remission
Retrospective Studies
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Summary:Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb-) has been reported. However, little is known about the clinicopathological characteristics and prognosis of this subtype. A total of 74 IMN patients with GAg + identified by kidney biopsy were enrolled in this study. We categorized patients into two groups based on the presence or absence of serum PLA2R antibody. Data on clinical features, pathological features, and outcomes were collected. Kaplan-Meier analysis of complete remission (CR) and partial remission (PR) comparing SAb-/GAg + and SAb+/GAg + patients. Cox proportional hazards models was used to examine factors associated with CR and PR. Among 74 IMN patients, 14 were SAb-/GAg+. Compared with SAb+/GAg + patients, SAb-/GAg + patients presented with higher levels of albumin, lower levels of cholesterol and low density lipoprotein cholesterol (all  
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2023.2297015