Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study

Background Osteonecrosis of the femoral head is a degenerative condition linked to corticosteroids, alcoholism, or trauma. With its rising prevalence due to increased hormone drug use and its debilitating effects on young to middle-aged individuals, understanding its association with specific labora...

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Published in:Journal of orthopaedic surgery and research 2023-10, Vol.18 (1), p.1-750, Article 750
Main Authors: Zheng, Haotian, Ye, Binglin, Huang, Kesong, Gao, Xiangming, Chen, Wei
Format: Article
Language:English
Subjects:
Age composition
Alcoholism
Biochemical Indicators
Blood
Care and treatment
Chinese medicine
Coagulation
Comparative analysis
Corticosteroids
Femoral head necrosis
Femur
Globulins
Health aspects
High density lipoprotein
Hip joint
Hospitals
Laboratories
Lipid metabolism
Lipids
Lipophilic
Low density lipoproteins
Medical diagnosis
Medical records
Metabolism
Necrosis
Orthopedics
Osteonecrosis
Protein turnover
Regression analysis
Retrospective cases
Risk factors
Routine blood
Statistical analysis
Steroids
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Summary:Background Osteonecrosis of the femoral head is a degenerative condition linked to corticosteroids, alcoholism, or trauma. With its rising prevalence due to increased hormone drug use and its debilitating effects on young to middle-aged individuals, understanding its association with specific laboratory indicators can aid early diagnosis and prevention. Methods Upon retrospective analysis of the clinical data pertaining to individuals diagnosed with femoral head necrosis, spanning from January 2016 to January 2022, a comprehensive evaluation was conducted within the same time frame. The study aimed to ascertain the presence of femoral head necrosis in a total of 1176 individuals. A total of 1036 healthy patients were recruited randomly, ensuring that their ages matched. The risk variables associated with the utilization of logistic regression analysis and analysis techniques are employed. The patient examines the age distribution within a specific age group. Results The levels of high-density lipoprotein, low-density lipoprotein A1, lipoprotein B1, total protein, albumin, globulin, and other lipophilic metabolism and coagulation markers exhibited a statistically significant increase compared to the control group. A multifactor logistic regression analysis was conducted to identify potential risk factors associated with femoral head necrosis in patients. Conclusion Femoral head necrosis is associated with a range of variables including coagulation malfunction, lipid metabolic abnormalities, and inflammation. Keywords: Femoral head necrosis, Routine blood, Biochemical Indicators, Retrospective cases, Risk factors
ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-023-04235-0